HPCwire: Complete Genomics Takes Off

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HPCwire >> Industry >> Life Sciences

October 15, 2008

Complete Genomics Takes Off

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Last week, San-Francisco-based Complete Genomics came out of stealth mode to become the first provider of large-scale human genome sequencing services. They claim to offer a third-generation genome sequencing technology that generates genomic data at a higher throughput than existing approaches and at lower cost.

What makes Complete Genomics different is that they are offering human genome sequencing as a service through their commercial-scale genome center. The technology and business model combine to enable large-scale human genomic population studies, thereby providing the basis for significant genomic analysis. By gathering and analyzing a large amount of genomic data, an individual's genetic profile data can be applied to disease prevention and management.

HPCwire recently asked company representatives to share some details about their work. Complete Genomics Chairman, President and CEO Dr. Clifford Reid and Vice President of Software Bruce Martin took the time to respond.

HPCwire: Can you describe the sequencing service and talk about the practical significance of its use in health care?

Dr. Clifford Reid: Complete Genomics is offering the industry's first large-scale human genome sequencing service for $5,000 per genome. We plan to sequence 1,000 complete human genomes in 2009 and 20,000 genomes in 2010. For the first time, companies and research institutions will be able to run large-scale complete human genome studies to understand the genetic basis of disease and drug response.

HPCwire: Can you provide a brief description of the technology pieces that make this sequencing service possible?

Reid: Complete Genomics has developed two breakthrough technologies that enable us to offer complete human genomes for $5,000. The first is a new method for creating extremely high density DNA arrays, which dramatically reduces the reagent and imaging cost of DNA sequencing. The second is a new ligation method of reading DNA, which dramatically reduces the reagent cost while maintaining the high accuracy of ligase-base DNA sequencing.

HPCwire: What is unique about the business model that allows you to do this?

Reid: By selling services rather than instruments, Complete Genomics is able to eliminate the burden of purchasing and operating complex and expensive DNA sequencing instruments, and eliminate the burden of building and operating a high-performance datacenter.

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