January 19, 2001


Columbus, OH, and McLean, VA — The Ohio State University (OSU), Ohio Supercomputer Center (OSC), and LabBook, Inc. announce that they have formed a partnership to provide life science researchers with an annotated map of the human genome. The project combines OSU’s annotated human genome database, backed by OSC’s computational power, with the powerful visualization and analysis capabilities of LabBook’s personal discovery space. The partnership allows scientists the most sophisticated view of the human genome to date.

In June 2000, the international consortium of the Human Genome Project announced that they had completed a map of the human genome sequence. However, this important milestone is just the first step in identifying the genes hidden in the sequence and understanding their function — a process known as annotation. Through a novel combination of data resources, and with computational power provided by OSC, researchers at OSU have identified thousands of genes and obtained clues to their function. LabBook’s genomic discovery system displays this information in a highly intuitive and interactive environment, enabling the researcher to extract meaning from the sequence.

The annotation project at OSU was directed by Dr. Bo Yuan, Head of Bioinformatics in the Human Genetics Cancer Program. “We have combined accurate, non-fragmented and non-redundant whole genome mapping of expressed genes with comprehensive annotation,” said Dr. Yuan. “Now we can truly perform hypothesis driven queries of the human genome, which was not previously possible.”

“Annotation is what makes the genome useful,” agreed Dr. Fred Wright of Human Cancer Genetics, “and we have drawn on several unique resources to discover the genes and how they work. The OSC contribution was critical, as this work would have literally taken years without their computing power while LabBook’s discovery system enables researchers to visualize this information in a beautifully integrated environment.” Dr. Wright expects that the LabBook software will accelerate efforts underway at OSU to identify genes involved in numerous diseases.

The process of annotation is extremely computationally-intensive, involving millions of automated searches and comparisons along the 3-billion letter code of the human DNA sequence. The necessary hardware is beyond the capabilities of most university or industry laboratories. The supercomputing cluster machines at OSC proved ideal for the job. “The generation of this database required a tremendous amount of computer power,” said Al Stutz of OSC. “We were fortunate to have the Silicon Graphics 1400 cluster that provided us with this capability.”

While genomic annotation provides a solid basis for genetic research, its usefulness remains limited without powerful software to perform queries and visualize the results. Moreover, the human genome project has been accompanied by an explosion of information on human genes, along with modern high-throughput technologies for analyzing their functions. This expanding collection of information for drug discovery holds the key to treatments for a broad range of human diseases, but the data sources are dispersed and of limited use to biologists who are not trained in bioinformatics. Utilizing the data effectively requires integrating these disparate data types in a unified Web environment. To solve this problem, OSU, LabBook and OSC are providing the OSU Human Genome Database within LabBook’s genomic discovery space.

“The OSU Human Genome Database and the way we deliver it to the scientist represent an important advance in extracting meaningful information from human genome data,” said Dr. Shawn Green, CEO of LabBook. “This meticulously assembled, comprehensively analyzed, extensively annotated, and carefully integrated research platform enables utilization of human genomic data in ways that have not been possible until now.”

LabBook’s genomic discovery space derives its power from the synthesis of four complementary information technologies: an exhaustively analyzed, and comprehensively annotated human gene database; a uniquely effective and discovery-based query engine; a dynamic XML-based data visualization interface through LabBook’s Genomic XML Browser(TM); and a functionally integrated Web- based information management system, the eLabBook(TM). The browser maximizes the value of bioinformatics data by delivering it as “live”, reusable documents in a highly visual and interactive discovery environment. The combination of an open XML standard for bioinformatics with a biology-smart browser creates the ideal bioinformatics ‘front end’ that enables dynamic integration and annotation of diverse data.

“To fully exploit the data derived from the sequencing of the human genome for advancing drug discovery it has to be accessible to virtually all biologists and not just the bioinformatics specialist,” said Dr. Adel Mikhail, LabBook’s Vice President of Corporate Development. “Our approach is to integrate and simplify bioinformatic information so that all interested biologists can effectively utilize this information.”

OSU’s Human Genome DataBase will be made available later this year at .

About OSU

The Ohio State University is a comprehensive land-grant teaching and research institution enrolling about 55,000 students system-wide annually, including 48,000 on its main Columbus campus. Operating on a $2.1 billion budget, which includes an academic Medical Center and one of the nation’s few free-standing cancer hospitals, the university attracted more than $228 million in external research funding last fiscal year. Ohio State offers 177 undergraduate majors, 120 master’s degree programs and 94 doctoral programs, with some 4,000 faculty teaching approximately 10,500 courses each year.

About LabBook, Inc.

LabBook, Inc. is an XML powered life science informatics and information provider for the biotechnology, pharmaceutical, and academic life science researcher. LabBook’s enabling software, such as the LabBook Genomic XML Browser(TM) queries, manages, and visualizes heterogeneous genomic data types while retaining their underlying associations, and then intelligently communicates targeted information to the researcher. LabBook’s open XML format and unique browser capabilities deliver genomic data as “live” reusable documents that integrate underlying bioinformatic content. LabBook’s mission is to solve the life science industry’s need for rapid access to targeted information and new discoveries. LabBook, Inc. offices are located in McLean, Virginia and Columbus, Ohio. To learn more contact LabBook, Inc. at .

About OSC

Ohio Supercomputer Center (OSC), a state-supported resource, provides a reliable high performance computing and communications infrastructure for a diverse, statewide/regional community of education, academic research, industry, and state government users. As a shared resource, OSC accelerates the use of information technologies to strengthen the state’s attractiveness and global competitiveness.

Web site:


Subscribe to HPCwire's Weekly Update!

Be the most informed person in the room! Stay ahead of the tech trends with industy updates delivered to you every week!

What’s New in Computing vs. COVID-19: Fugaku, Congress, De Novo Design & More

July 2, 2020

Supercomputing, big data and artificial intelligence are crucial tools in the fight against the coronavirus pandemic. Around the world, researchers, corporations and governments are urgently devoting their computing reso Read more…

By Oliver Peckham

OpenPOWER Reboot – New Director, New Silicon Partners, Leveraging Linux Foundation Connections

July 2, 2020

Earlier this week the OpenPOWER Foundation announced the contribution of IBM’s A21 Power processor core design to the open source community. Roughly this time last year, IBM announced open sourcing its Power instructio Read more…

By John Russell

HPC Career Notes: July 2020 Edition

July 1, 2020

In this monthly feature, we'll keep you up-to-date on the latest career developments for individuals in the high-performance computing community. Whether it's a promotion, new company hire, or even an accolade, we've got Read more…

By Mariana Iriarte

Supercomputers Enable Radical, Promising New COVID-19 Drug Development Approach

July 1, 2020

Around the world, innumerable supercomputers are sifting through billions of molecules in a desperate search for a viable therapeutic to treat COVID-19. Those molecules are pulled from enormous databases of known compoun Read more…

By Oliver Peckham

HPC-Powered Simulations Reveal a Looming Climatic Threat to Vital Monsoon Seasons

June 30, 2020

As June draws to a close, eyes are turning to the latter half of the year – and with it, the monsoon and hurricane seasons that can prove vital or devastating for many of the world’s coastal communities. Now, climate Read more…

By Oliver Peckham

AWS Solution Channel

Maxar Builds HPC on AWS to Deliver Forecasts 58% Faster Than Weather Supercomputer

When weather threatens drilling rigs, refineries, and other energy facilities, oil and gas companies want to move fast to protect personnel and equipment. And for firms that trade commodity shares in oil, precious metals, crops, and livestock, the weather can significantly impact their buy-sell decisions. Read more…

Intel® HPC + AI Pavilion

Supercomputing the Pandemic: Scientific Community Tackles COVID-19 from Multiple Perspectives

Since their inception, supercomputers have taken on the biggest, most complex, and most data-intensive computing challenges—from confirming Einstein’s theories about gravitational waves to predicting the impacts of climate change. Read more…

Hyperion Forecast – Headwinds in 2020 Won’t Stifle Cloud HPC Adoption or Arm’s Rise

June 30, 2020

The semiannual taking of HPC’s pulse by Hyperion Research – late fall at SC and early summer at ISC – is a much-watched indicator of things come. This year is no different though the conversion of ISC to a digital Read more…

By John Russell

OpenPOWER Reboot – New Director, New Silicon Partners, Leveraging Linux Foundation Connections

July 2, 2020

Earlier this week the OpenPOWER Foundation announced the contribution of IBM’s A21 Power processor core design to the open source community. Roughly this time Read more…

By John Russell

Hyperion Forecast – Headwinds in 2020 Won’t Stifle Cloud HPC Adoption or Arm’s Rise

June 30, 2020

The semiannual taking of HPC’s pulse by Hyperion Research – late fall at SC and early summer at ISC – is a much-watched indicator of things come. This yea Read more…

By John Russell

Racism and HPC: a Special Podcast

June 29, 2020

Promoting greater diversity in HPC is a much-discussed goal and ostensibly a long-sought goal in HPC. Yet it seems clear HPC is far from achieving this goal. Re Read more…

Top500 Trends: Movement on Top, but Record Low Turnover

June 25, 2020

The 55th installment of the Top500 list saw strong activity in the leadership segment with four new systems in the top ten and a crowning achievement from the f Read more…

By Tiffany Trader

ISC 2020 Keynote: Hope for the Future, Praise for Fugaku and HPC’s Pandemic Response

June 24, 2020

In stark contrast to past years Thomas Sterling’s ISC20 keynote today struck a more somber note with the COVID-19 pandemic as the central character in Sterling’s annual review of worldwide trends in HPC. Better known for his engaging manner and occasional willingness to poke prickly egos, Sterling instead strode through the numbing statistics associated... Read more…

By John Russell

ISC 2020’s Student Cluster Competition Winners Announced

June 24, 2020

Normally, the Student Cluster Competition involves teams of students building real computing clusters on the show floors of major supercomputer conferences and Read more…

By Oliver Peckham

Hoefler’s Whirlwind ISC20 Virtual Tour of ML Trends in 9 Slides

June 23, 2020

The ISC20 experience this year via livestreaming and pre-recordings is interesting and perhaps a bit odd. That said presenters’ efforts to condense their comments makes for economic use of your time. Torsten Hoefler’s whirlwind 12-minute tour of ML is a great example. Hoefler, leader of the planned ISC20 Machine Learning... Read more…

By John Russell

At ISC, the Fight Against COVID-19 Took the Stage – and Yes, Fugaku Was There

June 23, 2020

With over nine million infected and nearly half a million dead, the COVID-19 pandemic has seized the world’s attention for several months. It has also dominat Read more…

By Oliver Peckham

Supercomputer Modeling Tests How COVID-19 Spreads in Grocery Stores

April 8, 2020

In the COVID-19 era, many people are treating simple activities like getting gas or groceries with caution as they try to heed social distancing mandates and protect their own health. Still, significant uncertainty surrounds the relative risk of different activities, and conflicting information is prevalent. A team of Finnish researchers set out to address some of these uncertainties by... Read more…

By Oliver Peckham

[email protected] Turns Its Massive Crowdsourced Computer Network Against COVID-19

March 16, 2020

For gamers, fighting against a global crisis is usually pure fantasy – but now, it’s looking more like a reality. As supercomputers around the world spin up Read more…

By Oliver Peckham

[email protected] Rallies a Legion of Computers Against the Coronavirus

March 24, 2020

Last week, we highlighted [email protected], a massive, crowdsourced computer network that has turned its resources against the coronavirus pandemic sweeping the globe – but [email protected] isn’t the only game in town. The internet is buzzing with crowdsourced computing... Read more…

By Oliver Peckham

Global Supercomputing Is Mobilizing Against COVID-19

March 12, 2020

Tech has been taking some heavy losses from the coronavirus pandemic. Global supply chains have been disrupted, virtually every major tech conference taking place over the next few months has been canceled... Read more…

By Oliver Peckham

Supercomputer Simulations Reveal the Fate of the Neanderthals

May 25, 2020

For hundreds of thousands of years, neanderthals roamed the planet, eventually (almost 50,000 years ago) giving way to homo sapiens, which quickly became the do Read more…

By Oliver Peckham

DoE Expands on Role of COVID-19 Supercomputing Consortium

March 25, 2020

After announcing the launch of the COVID-19 High Performance Computing Consortium on Sunday, the Department of Energy yesterday provided more details on its sco Read more…

By John Russell

Steve Scott Lays Out HPE-Cray Blended Product Roadmap

March 11, 2020

Last week, the day before the El Capitan processor disclosures were made at HPE's new headquarters in San Jose, Steve Scott (CTO for HPC & AI at HPE, and former Cray CTO) was on-hand at the Rice Oil & Gas HPC conference in Houston. He was there to discuss the HPE-Cray transition and blended roadmap, as well as his favorite topic, Cray's eighth-gen networking technology, Slingshot. Read more…

By Tiffany Trader

Honeywell’s Big Bet on Trapped Ion Quantum Computing

April 7, 2020

Honeywell doesn’t spring to mind when thinking of quantum computing pioneers, but a decade ago the high-tech conglomerate better known for its control systems waded deliberately into the then calmer quantum computing (QC) waters. Fast forward to March when Honeywell announced plans to introduce an ion trap-based quantum computer whose ‘performance’ would... Read more…

By John Russell

Leading Solution Providers


Neocortex Will Be First-of-Its-Kind 800,000-Core AI Supercomputer

June 9, 2020

Pittsburgh Supercomputing Center (PSC - a joint research organization of Carnegie Mellon University and the University of Pittsburgh) has won a $5 million award Read more…

By Tiffany Trader

‘Billion Molecules Against COVID-19’ Challenge to Launch with Massive Supercomputing Support

April 22, 2020

Around the world, supercomputing centers have spun up and opened their doors for COVID-19 research in what may be the most unified supercomputing effort in hist Read more…

By Oliver Peckham

Australian Researchers Break All-Time Internet Speed Record

May 26, 2020

If you’ve been stuck at home for the last few months, you’ve probably become more attuned to the quality (or lack thereof) of your internet connection. Even Read more…

By Oliver Peckham

15 Slides on Programming Aurora and Exascale Systems

May 7, 2020

Sometime in 2021, Aurora, the first planned U.S. exascale system, is scheduled to be fired up at Argonne National Laboratory. Cray (now HPE) and Intel are the k Read more…

By John Russell

Nvidia’s Ampere A100 GPU: Up to 2.5X the HPC, 20X the AI

May 14, 2020

Nvidia's first Ampere-based graphics card, the A100 GPU, packs a whopping 54 billion transistors on 826mm2 of silicon, making it the world's largest seven-nanom Read more…

By Tiffany Trader

10nm, 7nm, 5nm…. Should the Chip Nanometer Metric Be Replaced?

June 1, 2020

The biggest cool factor in server chips is the nanometer. AMD beating Intel to a CPU built on a 7nm process node* – with 5nm and 3nm on the way – has been i Read more…

By Doug Black

Summit Supercomputer is Already Making its Mark on Science

September 20, 2018

Summit, now the fastest supercomputer in the world, is quickly making its mark in science – five of the six finalists just announced for the prestigious 2018 Read more…

By John Russell

TACC Supercomputers Run Simulations Illuminating COVID-19, DNA Replication

March 19, 2020

As supercomputers around the world spin up to combat the coronavirus, the Texas Advanced Computing Center (TACC) is announcing results that may help to illumina Read more…

By Staff report

  • arrow
  • Click Here for More Headlines
  • arrow
Do NOT follow this link or you will be banned from the site!
Share This