The Real Health Care Revolution Awaits

By Michael Feldman

March 11, 2010

The current political debate on US health care reform is depressing on so many levels. The fact that the wealthiest country in the world can’t seem to figure out a way to provide basic medical care for its citizens is discouraging enough. Worse, the current plan on the table will basically just bring more people into the 20th century-style health care model. In general, that model is reactionary: waiting for a disease or medical emergency to strike, and then treating the symptoms with drugs or surgery. The good news is that this style of medicine is going out of fashion.

In all likelihood, the new model is going to be something similar to what’s referred to as “P4” medicine (powerfully predictive, personalized, preventative). That is a term coined by biotech luminary Leroy Hood, president and cofounder of the Institute for Systems Biology in Seattle. The idea is to bring a P4 approach into the practice of health care, incorporating the rapidly advancing technologies of molecular immunology, biotechnology, genomics, and computer science. Hood’s non-profit Systems Biology institute is designed to bring together researchers from these fields and act as a incubator for P4-type biotech spinoffs.

Hood has been actively spreading the word about how this new approach will transform medicine. In fact, he was one of the plenary speakers at SC09 in Portland last November, where he talked about the way HPC fits into the systems biology paradigm. In a recent interview published in Technology Review, Hood spells out the basic outline of P4 medicine:

Individual genomes will become a standard of medical records in 10 years or so, and we will have the power to make inferences [about an individual’s health] when combined with phenotypic information. Then we can begin to plan strategies for individual health care in ways we have never done before.

The idea is to use knowledge of a person’s genome to deliver targeted treatments that optimize that individual’s health, ideally before disease strikes. The paradigm encompasses all the new biotech buzzwords: nanotechnology, genomics, proteomics, and metabolomics. Layered on top of all this is the computational know-how that will be used to turn the “omics” data into useful health care. Says Hood:

Medicine is going to become an information science. The whole health-care system requires a level of IT that goes beyond mere digitization of medical records, which is what most people are talking about now. In 10 years or so, we may have billions of data points on each individual, and the real challenge will be to develop information technology that can reduce that to real hypotheses about that individual.

Hood worries that we’ll be hard-pressed to come up with enough computational horsepower and storage capacity to deal with the genomic data for billions of people. I would be less concerned on that front. High performance computing and storage seems to be moving along at least as quickly as genome capturing technologies like DNA sequencing.

Connecting biotech with IT is the key, since this can move health care onto a Moore’s Law-like curve where the value per dollar increases exponentially over time. The current trajectory of 20th century-style medicine is unsustainable. According to the US Congressional Budget Office, health care costs are on track to reach 50 percent of GDP by the middle of the century and 100 percent by 2082. Obviously that can’t happen (see Stein’s Law).

Tweaking peoples’ genes to make them healthier and longer lived, via pharmagenomics and related technologies, is a much more economical approach. We already employ a low-tech version of this today when we make healthy lifestyle choices: exercising, eating well, getting regular sleep, and so on. All these activities can profoundly change our gene expression for the better. Being able to tune up our DNA and other cellular components in a more precise way would be the ultimate in preventive care. In fact, it would eradicate most of the costs associated with treating degenerative diseases — everything from cancer, heart disease and diabetes to Alzheimer’s. Preventing just these four diseases would eliminate a huge chunk of the health care bill.

In the meantime, we can watch the current health care debate in the US and hope we can at least achieve broader access to a 20th century medical system. But whatever happens, it’s probably not worth getting too stressed out about it. I’m told it’s not good for your health.

Subscribe to HPCwire's Weekly Update!

Be the most informed person in the room! Stay ahead of the tech trends with industy updates delivered to you every week!

Hedge Funds (with Supercomputing help) Rank First Among Investors

May 22, 2017

In case you didn’t know, The Quants Run Wall Street Now, or so says a headline in today’s Wall Street Journal. Quant-run hedge funds now control the largest Read more…

By John Russell

IBM, D-Wave Report Quantum Computing Advances

May 18, 2017

IBM said this week it has built and tested a pair of quantum computing processors, including a prototype of a commercial version. That progress follows an an Read more…

By George Leopold

PRACEdays 2017 Wraps Up in Barcelona

May 18, 2017

Barcelona has been absolutely lovely; the weather, the food, the people. I am, sadly, finishing my last day at PRACEdays 2017 with two sessions: an in-depth loo Read more…

By Kim McMahon

US, Europe, Japan Deepen Research Computing Partnership

May 18, 2017

On May 17, 2017, a ceremony was held during the PRACEdays 2017 conference in Barcelona to announce the memorandum of understanding (MOU) between PRACE in Europe Read more…

By Tiffany Trader

HPE Extreme Performance Solutions

Exploring the Three Models of Remote Visualization

The explosion of data and advancement of digital technologies are dramatically changing the way many companies do business. With the help of high performance computing (HPC) solutions and data analytics platforms, manufacturers are developing products faster, healthcare providers are improving patient care, and energy companies are improving planning, exploration, and production. Read more…

NSF, IARPA, and SRC Push into “Semiconductor Synthetic Biology” Computing

May 18, 2017

Research into how biological systems might be fashioned into computational technology has a long history with various DNA-based computing approaches explored. N Read more…

By John Russell

DOE’s HPC4Mfg Leads to Paper Manufacturing Improvement

May 17, 2017

Papermaking ranks third behind only petroleum refining and chemical production in terms of energy consumption. Recently, simulations made possible by the U.S. D Read more…

By John Russell

PRACEdays 2017: The start of a beautiful week in Barcelona

May 17, 2017

Touching down in Barcelona on Saturday afternoon, it was warm, sunny, and oh so Spanish. I was greeted at my hotel with a glass of Cava to sip and treated to a Read more…

By Kim McMahon

NSF Issues $60M RFP for “Towards a Leadership-Class” System

May 16, 2017

In case you missed it, the National Science Foundation issued the request for proposals (RFP) for the next ‘Towards a Leadership-Class Computing Facility – Read more…

By John Russell

Cray Offers Supercomputing as a Service, Targets Biotechs First

May 16, 2017

Leading supercomputer vendor Cray and datacenter/cloud provider the Markley Group today announced plans to jointly deliver supercomputing as a service. The init Read more…

By John Russell

HPE’s Memory-centric The Machine Coming into View, Opens ARMs to 3rd-party Developers

May 16, 2017

Announced three years ago, HPE’s The Machine is said to be the largest R&D program in the venerable company’s history, one that could be progressing tow Read more…

By Doug Black

What’s Up with Hyperion as It Transitions From IDC?

May 15, 2017

If you’re wondering what’s happening with Hyperion Research – formerly the IDC HPC group – apparently you are not alone, says Steve Conway, now senior V Read more…

By John Russell

Nvidia’s Mammoth Volta GPU Aims High for AI, HPC

May 10, 2017

At Nvidia's GPU Technology Conference (GTC17) in San Jose, Calif., this morning, CEO Jensen Huang announced the company's much-anticipated Volta architecture a Read more…

By Tiffany Trader

HPE Launches Servers, Services, and Collaboration at GTC

May 10, 2017

Hewlett Packard Enterprise (HPE) today launched a new liquid cooled GPU-driven Apollo platform based on SGI ICE architecture, a new collaboration with NVIDIA, a Read more…

By John Russell

IBM PowerAI Tools Aim to Ease Deep Learning Data Prep, Shorten Training 

May 10, 2017

A new set of GPU-powered AI software announced by IBM today brings automation to many of the tedious, time consuming and complex aspects of AI project on-rampin Read more…

By Doug Black

Bright Computing 8.0 Adds Azure, Expands Machine Learning Support

May 9, 2017

Bright Computing, long a prominent provider of cluster management tools for HPC, today released version 8.0 of Bright Cluster Manager and Bright OpenStack. The Read more…

By John Russell

Microsoft Azure Will Debut Pascal GPU Instances This Year

May 8, 2017

As Nvidia's GPU Technology Conference gets underway in San Jose, Calif., Microsoft today revealed plans to add Pascal-generation GPU horsepower to its Azure clo Read more…

By Tiffany Trader

Quantum Bits: D-Wave and VW; Google Quantum Lab; IBM Expands Access

March 21, 2017

For a technology that’s usually characterized as far off and in a distant galaxy, quantum computing has been steadily picking up steam. Just how close real-wo Read more…

By John Russell

Google Pulls Back the Covers on Its First Machine Learning Chip

April 6, 2017

This week Google released a report detailing the design and performance characteristics of the Tensor Processing Unit (TPU), its custom ASIC for the inference Read more…

By Tiffany Trader

Trump Budget Targets NIH, DOE, and EPA; No Mention of NSF

March 16, 2017

President Trump’s proposed U.S. fiscal 2018 budget issued today sharply cuts science spending while bolstering military spending as he promised during the cam Read more…

By John Russell

HPC Compiler Company PathScale Seeks Life Raft

March 23, 2017

HPCwire has learned that HPC compiler company PathScale has fallen on difficult times and is asking the community for help or actively seeking a buyer for its a Read more…

By Tiffany Trader

Nvidia Responds to Google TPU Benchmarking

April 10, 2017

Last week, Google reported that its custom ASIC Tensor Processing Unit (TPU) was 15-30x faster for inferencing workloads than Nvidia's K80 GPU (see our coverage Read more…

By Tiffany Trader

CPU-based Visualization Positions for Exascale Supercomputing

March 16, 2017

Since our first formal product releases of OSPRay and OpenSWR libraries in 2016, CPU-based Software Defined Visualization (SDVis) has achieved wide-spread adopt Read more…

By Jim Jeffers, Principal Engineer and Engineering Leader, Intel

TSUBAME3.0 Points to Future HPE Pascal-NVLink-OPA Server

February 17, 2017

Since our initial coverage of the TSUBAME3.0 supercomputer yesterday, more details have come to light on this innovative project. Of particular interest is a ne Read more…

By Tiffany Trader

Facebook Open Sources Caffe2; Nvidia, Intel Rush to Optimize

April 18, 2017

From its F8 developer conference in San Jose, Calif., today, Facebook announced Caffe2, a new open-source, cross-platform framework for deep learning. Caffe2 is Read more…

By Tiffany Trader

Leading Solution Providers

Nvidia’s Mammoth Volta GPU Aims High for AI, HPC

May 10, 2017

At Nvidia's GPU Technology Conference (GTC17) in San Jose, Calif., this morning, CEO Jensen Huang announced the company's much-anticipated Volta architecture a Read more…

By Tiffany Trader

Tokyo Tech’s TSUBAME3.0 Will Be First HPE-SGI Super

February 16, 2017

In a press event Friday afternoon local time in Japan, Tokyo Institute of Technology (Tokyo Tech) announced its plans for the TSUBAME3.0 supercomputer, which w Read more…

By Tiffany Trader

Is Liquid Cooling Ready to Go Mainstream?

February 13, 2017

Lost in the frenzy of SC16 was a substantial rise in the number of vendors showing server oriented liquid cooling technologies. Three decades ago liquid cooling Read more…

By Steve Campbell

MIT Mathematician Spins Up 220,000-Core Google Compute Cluster

April 21, 2017

On Thursday, Google announced that MIT math professor and computational number theorist Andrew V. Sutherland had set a record for the largest Google Compute Eng Read more…

By Tiffany Trader

IBM Wants to be “Red Hat” of Deep Learning

January 26, 2017

IBM today announced the addition of TensorFlow and Chainer deep learning frameworks to its PowerAI suite of deep learning tools, which already includes popular Read more…

By John Russell

HPC Technique Propels Deep Learning at Scale

February 21, 2017

Researchers from Baidu's Silicon Valley AI Lab (SVAIL) have adapted a well-known HPC communication technique to boost the speed and scale of their neural networ Read more…

By Tiffany Trader

US Supercomputing Leaders Tackle the China Question

March 15, 2017

As China continues to prove its supercomputing mettle via the Top500 list and the forward march of its ambitious plans to stand up an exascale machine by 2020, Read more…

By Tiffany Trader

DOE Supercomputer Achieves Record 45-Qubit Quantum Simulation

April 13, 2017

In order to simulate larger and larger quantum systems and usher in an age of "quantum supremacy," researchers are stretching the limits of today's most advance Read more…

By Tiffany Trader

  • arrow
  • Click Here for More Headlines
  • arrow
Share This