The Real Health Care Revolution Awaits

By Michael Feldman

March 11, 2010

The current political debate on US health care reform is depressing on so many levels. The fact that the wealthiest country in the world can’t seem to figure out a way to provide basic medical care for its citizens is discouraging enough. Worse, the current plan on the table will basically just bring more people into the 20th century-style health care model. In general, that model is reactionary: waiting for a disease or medical emergency to strike, and then treating the symptoms with drugs or surgery. The good news is that this style of medicine is going out of fashion.

In all likelihood, the new model is going to be something similar to what’s referred to as “P4” medicine (powerfully predictive, personalized, preventative). That is a term coined by biotech luminary Leroy Hood, president and cofounder of the Institute for Systems Biology in Seattle. The idea is to bring a P4 approach into the practice of health care, incorporating the rapidly advancing technologies of molecular immunology, biotechnology, genomics, and computer science. Hood’s non-profit Systems Biology institute is designed to bring together researchers from these fields and act as a incubator for P4-type biotech spinoffs.

Hood has been actively spreading the word about how this new approach will transform medicine. In fact, he was one of the plenary speakers at SC09 in Portland last November, where he talked about the way HPC fits into the systems biology paradigm. In a recent interview published in Technology Review, Hood spells out the basic outline of P4 medicine:

Individual genomes will become a standard of medical records in 10 years or so, and we will have the power to make inferences [about an individual’s health] when combined with phenotypic information. Then we can begin to plan strategies for individual health care in ways we have never done before.

The idea is to use knowledge of a person’s genome to deliver targeted treatments that optimize that individual’s health, ideally before disease strikes. The paradigm encompasses all the new biotech buzzwords: nanotechnology, genomics, proteomics, and metabolomics. Layered on top of all this is the computational know-how that will be used to turn the “omics” data into useful health care. Says Hood:

Medicine is going to become an information science. The whole health-care system requires a level of IT that goes beyond mere digitization of medical records, which is what most people are talking about now. In 10 years or so, we may have billions of data points on each individual, and the real challenge will be to develop information technology that can reduce that to real hypotheses about that individual.

Hood worries that we’ll be hard-pressed to come up with enough computational horsepower and storage capacity to deal with the genomic data for billions of people. I would be less concerned on that front. High performance computing and storage seems to be moving along at least as quickly as genome capturing technologies like DNA sequencing.

Connecting biotech with IT is the key, since this can move health care onto a Moore’s Law-like curve where the value per dollar increases exponentially over time. The current trajectory of 20th century-style medicine is unsustainable. According to the US Congressional Budget Office, health care costs are on track to reach 50 percent of GDP by the middle of the century and 100 percent by 2082. Obviously that can’t happen (see Stein’s Law).

Tweaking peoples’ genes to make them healthier and longer lived, via pharmagenomics and related technologies, is a much more economical approach. We already employ a low-tech version of this today when we make healthy lifestyle choices: exercising, eating well, getting regular sleep, and so on. All these activities can profoundly change our gene expression for the better. Being able to tune up our DNA and other cellular components in a more precise way would be the ultimate in preventive care. In fact, it would eradicate most of the costs associated with treating degenerative diseases — everything from cancer, heart disease and diabetes to Alzheimer’s. Preventing just these four diseases would eliminate a huge chunk of the health care bill.

In the meantime, we can watch the current health care debate in the US and hope we can at least achieve broader access to a 20th century medical system. But whatever happens, it’s probably not worth getting too stressed out about it. I’m told it’s not good for your health.

Subscribe to HPCwire's Weekly Update!

Be the most informed person in the room! Stay ahead of the tech trends with industy updates delivered to you every week!

IBM Quantum Update: Q System One Launch, New Collaborators, and QC Center Plans

January 10, 2019

IBM made three significant quantum computing announcements at CES this week. One was introduction of IBM Q System One; it’s really the integration of IBM’s existing 20-quibit platform into a more robust, self-contain Read more…

By John Russell

Intel at CES: Nervana; 10nm Server CPU; Cascade Lake

January 9, 2019

On the eve of the Consumer Electronics Show in Las Vegas this week, Intel staged a launch event that covered a new version of its Nervana AI processor and a demonstration of the next-generation Xeon 10nm chip. The Read more…

By Staff

IBM’s New Global Weather Forecasting System Runs on GPUs

January 9, 2019

Anyone who has checked a forecast to decide whether or not to pack an umbrella knows that weather prediction can be a mercurial endeavor. It is a Herculean task: the constant modeling of incredibly complex systems to a high degree of accuracy at a local level within very short spans of time. Read more…

By Oliver Peckham

HPE Extreme Performance Solutions

HPE Systems With Intel Omni-Path: Architected for Value and Accessible High-Performance Computing

Today’s high-performance computing (HPC) and artificial intelligence (AI) users value high performing clusters. And the higher the performance that their system can deliver, the better. Read more…

IBM Accelerated Insights

Data: The Key To Unlocking Modern Research

Research tackles the big questions, delving into uncharted territory in pursuit of knowledge that could change the world. Today’s research simulations are generating more data than ever before, a trend that shows no signs of slowing. Read more…

The Case Against ‘The Case Against Quantum Computing’

January 9, 2019

It’s not easy to be a physicist. Richard Feynman (basically the Jimi Hendrix of physicists) once said: “The first principle is that you must not fool yourself – and you are the easiest person to fool.” This maxim Read more…

By Ben Criger

IBM Quantum Update: Q System One Launch, New Collaborators, and QC Center Plans

January 10, 2019

IBM made three significant quantum computing announcements at CES this week. One was introduction of IBM Q System One; it’s really the integration of IBM’s Read more…

By John Russell

IBM’s New Global Weather Forecasting System Runs on GPUs

January 9, 2019

Anyone who has checked a forecast to decide whether or not to pack an umbrella knows that weather prediction can be a mercurial endeavor. It is a Herculean task: the constant modeling of incredibly complex systems to a high degree of accuracy at a local level within very short spans of time. Read more…

By Oliver Peckham

The Case Against ‘The Case Against Quantum Computing’

January 9, 2019

It’s not easy to be a physicist. Richard Feynman (basically the Jimi Hendrix of physicists) once said: “The first principle is that you must not fool yourse Read more…

By Ben Criger

The Deep500 – Researchers Tackle an HPC Benchmark for Deep Learning

January 7, 2019

How do you know if an HPC system, particularly a larger-scale system, is well-suited for deep learning workloads? Today, that’s not an easy question to answer Read more…

By John Russell

HPCwire Awards Highlight Supercomputing Achievements in the Sciences

January 3, 2019

In November at SC18 in Dallas, HPCwire Readers’ and Editors’ Choice awards program commemorated its 15th year of honoring achievement in HPC, with categories ranging from Best Use of AI to the Workforce Diversity Leadership Award and recipients across a wide variety of industrial and research sectors. Read more…

By the Editorial Team

White House Top Science Post Filled After Two-Year Vacancy

January 3, 2019

Half-way into Trump's term, the Senate has confirmed a director for the Office of Science and Technology Policy (OSTP), the agency that coordinates science poli Read more…

By Tiffany Trader

Batswana Gems

December 20, 2018

Most who work in the high-performance computing (HPC) industry agree; people problems are far more complicated than technical challenges. As I wrote in a 2015 HPCwire feature titled, “Women in HPC: Revelations and Reckoning,” diversity, or the lack thereof, is the HPC industry’s current grand challenge. Read more…

By Elizabeth Leake

HPC Reflections and (Mostly Hopeful) Predictions

December 19, 2018

So much ‘spaghetti’ gets tossed on walls by the technology community (vendors and researchers) to see what sticks that it is often difficult to peer through Read more…

By John Russell

Quantum Computing Will Never Work

November 27, 2018

Amid the gush of money and enthusiastic predictions being thrown at quantum computing comes a proposed cold shower in the form of an essay by physicist Mikhail Read more…

By John Russell

Cray Unveils Shasta, Lands NERSC-9 Contract

October 30, 2018

Cray revealed today the details of its next-gen supercomputing architecture, Shasta, selected to be the next flagship system at NERSC. We've known of the code-name "Shasta" since the Argonne slice of the CORAL project was announced in 2015 and although the details of that plan have changed considerably, Cray didn't slow down its timeline for Shasta. Read more…

By Tiffany Trader

Summit Supercomputer is Already Making its Mark on Science

September 20, 2018

Summit, now the fastest supercomputer in the world, is quickly making its mark in science – five of the six finalists just announced for the prestigious 2018 Read more…

By John Russell

AMD Sets Up for Epyc Epoch

November 16, 2018

It’s been a good two weeks, AMD’s Gary Silcott and Andy Parma told me on the last day of SC18 in Dallas at the restaurant where we met to discuss their show news and recent successes. Heck, it’s been a good year. Read more…

By Tiffany Trader

US Leads Supercomputing with #1, #2 Systems & Petascale Arm

November 12, 2018

The 31st Supercomputing Conference (SC) - commemorating 30 years since the first Supercomputing in 1988 - kicked off in Dallas yesterday, taking over the Kay Ba Read more…

By Tiffany Trader

House Passes $1.275B National Quantum Initiative

September 17, 2018

Last Thursday the U.S. House of Representatives passed the National Quantum Initiative Act (NQIA) intended to accelerate quantum computing research and developm Read more…

By John Russell

The Case Against ‘The Case Against Quantum Computing’

January 9, 2019

It’s not easy to be a physicist. Richard Feynman (basically the Jimi Hendrix of physicists) once said: “The first principle is that you must not fool yourse Read more…

By Ben Criger

Contract Signed for New Finnish Supercomputer

December 13, 2018

After the official contract signing yesterday, configuration details were made public for the new BullSequana system that the Finnish IT Center for Science (CSC Read more…

By Tiffany Trader

Leading Solution Providers

SC 18 Virtual Booth Video Tour

Advania @ SC18 AMD @ SC18
ASRock Rack @ SC18
DDN Storage @ SC18
HPE @ SC18
IBM @ SC18
Lenovo @ SC18 Mellanox Technologies @ SC18
NVIDIA @ SC18
One Stop Systems @ SC18
Oracle @ SC18 Panasas @ SC18
Supermicro @ SC18 SUSE @ SC18 TYAN @ SC18
Verne Global @ SC18

Nvidia’s Jensen Huang Delivers Vision for the New HPC

November 14, 2018

For nearly two hours on Monday at SC18, Jensen Huang, CEO of Nvidia, presented his expansive view of the future of HPC (and computing in general) as only he can do. Animated. Backstopped by a stream of data charts, product photos, and even a beautiful image of supernovae... Read more…

By John Russell

HPE No. 1, IBM Surges, in ‘Bucking Bronco’ High Performance Server Market

September 27, 2018

Riding healthy U.S. and global economies, strong demand for AI-capable hardware and other tailwind trends, the high performance computing server market jumped 28 percent in the second quarter 2018 to $3.7 billion, up from $2.9 billion for the same period last year, according to industry analyst firm Hyperion Research. Read more…

By Doug Black

HPC Reflections and (Mostly Hopeful) Predictions

December 19, 2018

So much ‘spaghetti’ gets tossed on walls by the technology community (vendors and researchers) to see what sticks that it is often difficult to peer through Read more…

By John Russell

Intel Confirms 48-Core Cascade Lake-AP for 2019

November 4, 2018

As part of the run-up to SC18, taking place in Dallas next week (Nov. 11-16), Intel is doling out info on its next-gen Cascade Lake family of Xeon processors, specifically the “Advanced Processor” version (Cascade Lake-AP), architected for high-performance computing, artificial intelligence and infrastructure-as-a-service workloads. Read more…

By Tiffany Trader

Germany Celebrates Launch of Two Fastest Supercomputers

September 26, 2018

The new high-performance computer SuperMUC-NG at the Leibniz Supercomputing Center (LRZ) in Garching is the fastest computer in Germany and one of the fastest i Read more…

By Tiffany Trader

Houston to Field Massive, ‘Geophysically Configured’ Cloud Supercomputer

October 11, 2018

Based on some news stories out today, one might get the impression that the next system to crack number one on the Top500 would be an industrial oil and gas mon Read more…

By Tiffany Trader

Microsoft to Buy Mellanox?

December 20, 2018

Networking equipment powerhouse Mellanox could be an acquisition target by Microsoft, according to a published report in an Israeli financial publication. Microsoft has reportedly gone so far as to engage Goldman Sachs to handle negotiations with Mellanox. Read more…

By Doug Black

The Deep500 – Researchers Tackle an HPC Benchmark for Deep Learning

January 7, 2019

How do you know if an HPC system, particularly a larger-scale system, is well-suited for deep learning workloads? Today, that’s not an easy question to answer Read more…

By John Russell

  • arrow
  • Click Here for More Headlines
  • arrow
Do NOT follow this link or you will be banned from the site!
Share This