The Real Health Care Revolution Awaits

By Michael Feldman

March 11, 2010

The current political debate on US health care reform is depressing on so many levels. The fact that the wealthiest country in the world can’t seem to figure out a way to provide basic medical care for its citizens is discouraging enough. Worse, the current plan on the table will basically just bring more people into the 20th century-style health care model. In general, that model is reactionary: waiting for a disease or medical emergency to strike, and then treating the symptoms with drugs or surgery. The good news is that this style of medicine is going out of fashion.

In all likelihood, the new model is going to be something similar to what’s referred to as “P4” medicine (powerfully predictive, personalized, preventative). That is a term coined by biotech luminary Leroy Hood, president and cofounder of the Institute for Systems Biology in Seattle. The idea is to bring a P4 approach into the practice of health care, incorporating the rapidly advancing technologies of molecular immunology, biotechnology, genomics, and computer science. Hood’s non-profit Systems Biology institute is designed to bring together researchers from these fields and act as a incubator for P4-type biotech spinoffs.

Hood has been actively spreading the word about how this new approach will transform medicine. In fact, he was one of the plenary speakers at SC09 in Portland last November, where he talked about the way HPC fits into the systems biology paradigm. In a recent interview published in Technology Review, Hood spells out the basic outline of P4 medicine:

Individual genomes will become a standard of medical records in 10 years or so, and we will have the power to make inferences [about an individual’s health] when combined with phenotypic information. Then we can begin to plan strategies for individual health care in ways we have never done before.

The idea is to use knowledge of a person’s genome to deliver targeted treatments that optimize that individual’s health, ideally before disease strikes. The paradigm encompasses all the new biotech buzzwords: nanotechnology, genomics, proteomics, and metabolomics. Layered on top of all this is the computational know-how that will be used to turn the “omics” data into useful health care. Says Hood:

Medicine is going to become an information science. The whole health-care system requires a level of IT that goes beyond mere digitization of medical records, which is what most people are talking about now. In 10 years or so, we may have billions of data points on each individual, and the real challenge will be to develop information technology that can reduce that to real hypotheses about that individual.

Hood worries that we’ll be hard-pressed to come up with enough computational horsepower and storage capacity to deal with the genomic data for billions of people. I would be less concerned on that front. High performance computing and storage seems to be moving along at least as quickly as genome capturing technologies like DNA sequencing.

Connecting biotech with IT is the key, since this can move health care onto a Moore’s Law-like curve where the value per dollar increases exponentially over time. The current trajectory of 20th century-style medicine is unsustainable. According to the US Congressional Budget Office, health care costs are on track to reach 50 percent of GDP by the middle of the century and 100 percent by 2082. Obviously that can’t happen (see Stein’s Law).

Tweaking peoples’ genes to make them healthier and longer lived, via pharmagenomics and related technologies, is a much more economical approach. We already employ a low-tech version of this today when we make healthy lifestyle choices: exercising, eating well, getting regular sleep, and so on. All these activities can profoundly change our gene expression for the better. Being able to tune up our DNA and other cellular components in a more precise way would be the ultimate in preventive care. In fact, it would eradicate most of the costs associated with treating degenerative diseases — everything from cancer, heart disease and diabetes to Alzheimer’s. Preventing just these four diseases would eliminate a huge chunk of the health care bill.

In the meantime, we can watch the current health care debate in the US and hope we can at least achieve broader access to a 20th century medical system. But whatever happens, it’s probably not worth getting too stressed out about it. I’m told it’s not good for your health.

Subscribe to HPCwire's Weekly Update!

Be the most informed person in the room! Stay ahead of the tech trends with industry updates delivered to you every week!

Weekly Wire Roundup: July 8-July 12, 2024

July 12, 2024

HPC news can get pretty sleepy in June and July, but this week saw a bump in activity midweek as Americans realized they still had work to do after the previous holiday weekend. The world outside the United States also s Read more…

Nvidia, Intel not Welcomed in New Apple AI and HPC Development Tools

July 12, 2024

New Mac developer tools will leverage Apple's homegrown chips, limiting HPC users' ability to use parallel programming frameworks from Intel or Nvidia. Apple's latest programming framework, Xcode 16, was introduced at Read more…

Virga: Australia’s New HPC and AI Powerhouse

July 11, 2024

Australia has officially added another supercomputer to the TOP500 list with the implementation of Virga. Officially coming online in June 2024, Virga is the newest HPC system to come out of the Australian Commonwealth S Read more…

NSF Issues Next Solicitation and More Detail on National Quantum Virtual Laboratory

July 10, 2024

After percolating for roughly a year, NSF has issued the next solicitation for the National Quantum Virtual Lab program — this one focused on design and implementation phases of the Quantum Quantum Science and Technolo Read more…

NCSA’s SEAS Team Keeps APACE of AlphaFold2

July 9, 2024

High-performance computing (HPC) can often be challenging for researchers to use because it requires expertise in working with large datasets, scaling the software, and selecting the best user interface. The National Read more…

Anders Jensen on Europe’s Plan for AI-optimized Supercomputers, Welcoming the UK, and More

July 8, 2024

The recent ISC24 conference in Hamburg showcased LUMI and other leadership-class supercomputers co-funded by the EuroHPC Joint Undertaking (JU), including three of the 10 highest-ranking Top500 systems, but some other ne Read more…

Shutterstock 2203611339

NSF Issues Next Solicitation and More Detail on National Quantum Virtual Laboratory

July 10, 2024

After percolating for roughly a year, NSF has issued the next solicitation for the National Quantum Virtual Lab program — this one focused on design and imple Read more…

NCSA’s SEAS Team Keeps APACE of AlphaFold2

July 9, 2024

High-performance computing (HPC) can often be challenging for researchers to use because it requires expertise in working with large datasets, scaling the softw Read more…

Anders Jensen on Europe’s Plan for AI-optimized Supercomputers, Welcoming the UK, and More

July 8, 2024

The recent ISC24 conference in Hamburg showcased LUMI and other leadership-class supercomputers co-funded by the EuroHPC Joint Undertaking (JU), including three Read more…

Generative AI to Account for 1.5% of World’s Power Consumption by 2029

July 8, 2024

Generative AI will take on a larger chunk of the world's power consumption to keep up with the hefty hardware requirements to run applications. "AI chips repres Read more…

US Senators Propose $32 Billion in Annual AI Spending, but Critics Remain Unconvinced

July 5, 2024

Senate leader, Chuck Schumer, and three colleagues want the US government to spend at least $32 billion annually by 2026 for non-defense related AI systems.  T Read more…

Point and Click HPC: High-Performance Desktops

July 3, 2024

Recently, an interesting paper appeared on Arvix called Use Cases for High-Performance Research Desktops. To be clear, the term desktop in this context does not Read more…

IonQ Plots Path to Commercial (Quantum) Advantage

July 2, 2024

IonQ, the trapped ion quantum computing specialist, delivered a progress report last week firming up 2024/25 product goals and reviewing its technology roadmap. Read more…

Shutterstock_1687123447

Nvidia Economics: Make $5-$7 for Every $1 Spent on GPUs

June 30, 2024

Nvidia is saying that companies could make $5 to $7 for every $1 invested in GPUs over a four-year period. Customers are investing billions in new Nvidia hardwa Read more…

Atos Outlines Plans to Get Acquired, and a Path Forward

May 21, 2024

Atos – via its subsidiary Eviden – is the second major supercomputer maker outside of HPE, while others have largely dropped out. The lack of integrators and Atos' financial turmoil have the HPC market worried. If Atos goes under, HPE will be the only major option for building large-scale systems. Read more…

Everyone Except Nvidia Forms Ultra Accelerator Link (UALink) Consortium

May 30, 2024

Consider the GPU. An island of SIMD greatness that makes light work of matrix math. Originally designed to rapidly paint dots on a computer monitor, it was then Read more…

Comparing NVIDIA A100 and NVIDIA L40S: Which GPU is Ideal for AI and Graphics-Intensive Workloads?

October 30, 2023

With long lead times for the NVIDIA H100 and A100 GPUs, many organizations are looking at the new NVIDIA L40S GPU, which it’s a new GPU optimized for AI and g Read more…

Nvidia’s New Blackwell GPU Can Train AI Models with Trillions of Parameters

March 18, 2024

Nvidia's latest and fastest GPU, codenamed Blackwell, is here and will underpin the company's AI plans this year. The chip offers performance improvements from Read more…

Shutterstock_1687123447

Nvidia Economics: Make $5-$7 for Every $1 Spent on GPUs

June 30, 2024

Nvidia is saying that companies could make $5 to $7 for every $1 invested in GPUs over a four-year period. Customers are investing billions in new Nvidia hardwa Read more…

Nvidia Shipped 3.76 Million Data-center GPUs in 2023, According to Study

June 10, 2024

Nvidia had an explosive 2023 in data-center GPU shipments, which totaled roughly 3.76 million units, according to a study conducted by semiconductor analyst fir Read more…

Some Reasons Why Aurora Didn’t Take First Place in the Top500 List

May 15, 2024

The makers of the Aurora supercomputer, which is housed at the Argonne National Laboratory, gave some reasons why the system didn't make the top spot on the Top Read more…

Nvidia H100: Are 550,000 GPUs Enough for This Year?

August 17, 2023

The GPU Squeeze continues to place a premium on Nvidia H100 GPUs. In a recent Financial Times article, Nvidia reports that it expects to ship 550,000 of its lat Read more…

Leading Solution Providers

Contributors

AMD Clears Up Messy GPU Roadmap, Upgrades Chips Annually

June 3, 2024

In the world of AI, there's a desperate search for an alternative to Nvidia's GPUs, and AMD is stepping up to the plate. AMD detailed its updated GPU roadmap, w Read more…

Intel’s Next-gen Falcon Shores Coming Out in Late 2025 

April 30, 2024

It's a long wait for customers hanging on for Intel's next-generation GPU, Falcon Shores, which will be released in late 2025.  "Then we have a rich, a very Read more…

Google Announces Sixth-generation AI Chip, a TPU Called Trillium

May 17, 2024

On Tuesday May 14th, Google announced its sixth-generation TPU (tensor processing unit) called Trillium.  The chip, essentially a TPU v6, is the company's l Read more…

Choosing the Right GPU for LLM Inference and Training

December 11, 2023

Accelerating the training and inference processes of deep learning models is crucial for unleashing their true potential and NVIDIA GPUs have emerged as a game- Read more…

IonQ Plots Path to Commercial (Quantum) Advantage

July 2, 2024

IonQ, the trapped ion quantum computing specialist, delivered a progress report last week firming up 2024/25 product goals and reviewing its technology roadmap. Read more…

The NASA Black Hole Plunge

May 7, 2024

We have all thought about it. No one has done it, but now, thanks to HPC, we see what it looks like. Hold on to your feet because NASA has released videos of wh Read more…

Q&A with Nvidia’s Chief of DGX Systems on the DGX-GB200 Rack-scale System

March 27, 2024

Pictures of Nvidia's new flagship mega-server, the DGX GB200, on the GTC show floor got favorable reactions on social media for the sheer amount of computing po Read more…

MLPerf Inference 4.0 Results Showcase GenAI; Nvidia Still Dominates

March 28, 2024

There were no startling surprises in the latest MLPerf Inference benchmark (4.0) results released yesterday. Two new workloads — Llama 2 and Stable Diffusion Read more…

  • arrow
  • Click Here for More Headlines
  • arrow
HPCwire