Migrating Legacy Applications to the Cloud

By Bruce Maches

June 27, 2010

One of the biggest issues that life science CIOs deal with is maintaining their inventory of legacy systems. These types of companies all have large portfolios of applications built up over the years using a variety of technologies and platforms. Many of these applications are very complicated point solutions performing specific functions in the drug or device development process. A good portion of these applications, because they deal with drug data, formulation, chemistry, patient data or manufacturing fall under the auspices of 21 CFR Part 11 and have been validated to meet FDA regulatory guidelines.

The crux of the problem is that life science CIOs have to ensure the continuing performance and availability of these older systems and applications. It is not uncommon to walk into the data center of a large pharmaceutical firm and find systems that are 5-10 years old or older still in use as part of the R&D process. This issue causes a whole slew of different problems:

– The need to maintain obsolete or no longer supported technologies or ones where the vendor no longer exists

– Expensive data center space tied up with older systems

– Keeping the necessary skilled resources knowledgeable on staff to provide support for these systems

– The associated costs of support, maintenance and licensing when budgets are already being squeezed

– Tying up resources that are maintaining these systems that could better be used elsewhere 

– Issues integrating these older systems with newly deployed applications

– Increased power/cooling requirements for older, less efficient systems

– Providing backup/recovery support

Why does this problem exist? There are a number of reasons that life science CIO’s are faced with these issues. Many of these systems were deployed having gone through the time consuming and expensive IQ/OQ/PQ Part 11 compliance process and most companies would rather invest in new systems than spend scarce funds upgrading and re-validating existing systems, other reasons include:

– FDA requirements that all data on any drug product must be kept for several years after the last sale to the public (think Aspirin here)

– Lack of funds to go through an expensive re-validation process  required for any major upgrade of an already validated system

– Multiple company mergers where sufficient funds were never allocated to fully integrate the IT functions

– Scientists who insist on using specific systems they know or are experienced with for their work

– Funding for new projects many times does not include money for retiring the system  being replaced so you end up with both the old and the new

All of these factors come together so that is it just basically easier to implement new systems and keep the existing ones alive. The life science CIO ends up watching his data center and personnel resources slowly being chewed up by the need to maintain older validated applications. 

What can be done to solve this problem? Prior to the advent of cloud computing the life science CIO did not have much in the way of real alternatives to deal with these issues. Now they can have the ability to move these legacy applications into a cloud based environment.

So, the question is, how do you go about getting this done? First of all, this not something that would be undertaken lightly. You would need to have a complete inventory and understanding of your existing legacy application environment. This would be to determine which systems are potential candidates for moving to the cloud, how critical those systems are, and what risks are associated with the move. You would also need an existing cloud strategy for your IT organization along with assessing the security risks, how users would still access those legacy applications, and what type of cloud environment would be appropriate and acceptable from a risk and regulatory standpoint. Once you have determined which systems can be migrated you would need to take the following very high level steps:

– Create a validated machine image (using the IQ process explained in a prior post) of the complete software environment for the platforms to be migrated, this can be re-used for any similarly configured systems

– Use database tools or write programs to extract the data from the legacy application

– Create a documented and validated process for the actual transferring of the data that would fully ensure that there is no data loss or corruption during this process

– Perform the migration itself keeping a record of all logs, check sums, record totals or whatever other check points are being used to ensure proper migration

Migrating legacy applications to the cloud is not something to be done lightly. It takes a real understanding of your existing systems, a disciplined process for the migration itself, and the ability to secure both data and access to these systems once they are migrated.

If you are a life science CIO you would jump at the chance to remove these systems from your on-site application portfolio. Imagine not having to deal with support, hardware issues on obsolete equipment, reducing your data center foot print, power consumption, and backup requirements. You would also free up critical personnel resources to focus on the goals and objectives of your business and isn’t that what the CIO is supposed to be doing?

Subscribe to HPCwire's Weekly Update!

Be the most informed person in the room! Stay ahead of the tech trends with industy updates delivered to you every week!

Advancing Modular Supercomputing with DEEP and DEEP-ER Architectures

February 24, 2017

Knowing that the jump to exascale will require novel architectural approaches capable of delivering dramatic efficiency and performance gains, researchers around the world are hard at work on next-generation HPC systems. Read more…

By Sean Thielen

Weekly Twitter Roundup (Feb. 23, 2017)

February 23, 2017

Here at HPCwire, we aim to keep the HPC community apprised of the most relevant and interesting news items that get tweeted throughout the week. Read more…

By Thomas Ayres

HPE Server Shows Low Latency on STAC-N1 Test

February 22, 2017

The performance of trade and match servers can be a critical differentiator for financial trading houses. Read more…

By John Russell

HPC Financial Update (Feb. 2017)

February 22, 2017

In this recurring feature, we’ll provide you with financial highlights from companies in the HPC industry. Check back in regularly for an updated list with the most pertinent fiscal information. Read more…

By Thomas Ayres

HPE Extreme Performance Solutions

O&G Companies Create Value with High Performance Remote Visualization

Today’s oil and gas (O&G) companies are striving to process datasets that have become not only tremendously large, but extremely complex. And the larger that data becomes, the harder it is to move and analyze it – particularly with a workforce that could be distributed between drilling sites, offshore rigs, and remote offices. Read more…

Rethinking HPC Platforms for ‘Second Gen’ Applications

February 22, 2017

Just what constitutes HPC and how best to support it is a keen topic currently. Read more…

By John Russell

HPC Technique Propels Deep Learning at Scale

February 21, 2017

Researchers from Baidu’s Silicon Valley AI Lab (SVAIL) have adapted a well-known HPC communication technique to boost the speed and scale of their neural network training and now they are sharing their implementation with the larger deep learning community. Read more…

By Tiffany Trader

IDC: Will the Real Exascale Race Please Stand Up?

February 21, 2017

So the exascale race is on. And lots of organizations are in the pack. Government announcements from the US, China, India, Japan, and the EU indicate that they are working hard to make it happen – some sooner, some later. Read more…

By Bob Sorensen, IDC

ExxonMobil, NCSA, Cray Scale Reservoir Simulation to 700,000+ Processors

February 17, 2017

In a scaling breakthrough for oil and gas discovery, ExxonMobil geoscientists report they have harnessed the power of 717,000 processors – the equivalent of 22,000 32-processor computers – to run complex oil and gas reservoir simulation models. Read more…

By Doug Black

Advancing Modular Supercomputing with DEEP and DEEP-ER Architectures

February 24, 2017

Knowing that the jump to exascale will require novel architectural approaches capable of delivering dramatic efficiency and performance gains, researchers around the world are hard at work on next-generation HPC systems. Read more…

By Sean Thielen

HPC Technique Propels Deep Learning at Scale

February 21, 2017

Researchers from Baidu’s Silicon Valley AI Lab (SVAIL) have adapted a well-known HPC communication technique to boost the speed and scale of their neural network training and now they are sharing their implementation with the larger deep learning community. Read more…

By Tiffany Trader

IDC: Will the Real Exascale Race Please Stand Up?

February 21, 2017

So the exascale race is on. And lots of organizations are in the pack. Government announcements from the US, China, India, Japan, and the EU indicate that they are working hard to make it happen – some sooner, some later. Read more…

By Bob Sorensen, IDC

TSUBAME3.0 Points to Future HPE Pascal-NVLink-OPA Server

February 17, 2017

Since our initial coverage of the TSUBAME3.0 supercomputer yesterday, more details have come to light on this innovative project. Of particular interest is a new board design for NVLink-equipped Pascal P100 GPUs that will create another entrant to the space currently occupied by Nvidia's DGX-1 system, IBM's "Minsky" platform and the Supermicro SuperServer (1028GQ-TXR). Read more…

By Tiffany Trader

Tokyo Tech’s TSUBAME3.0 Will Be First HPE-SGI Super

February 16, 2017

In a press event Friday afternoon local time in Japan, Tokyo Institute of Technology (Tokyo Tech) announced its plans for the TSUBAME3.0 supercomputer, which will be Japan’s “fastest AI supercomputer,” Read more…

By Tiffany Trader

Drug Developers Use Google Cloud HPC in the Fight Against ALS

February 16, 2017

Within the haystack of a lethal disease such as ALS (amyotrophic lateral sclerosis / Lou Gehrig’s Disease) there exists, somewhere, the needle that will pierce this therapy-resistant affliction. Read more…

By Doug Black

Azure Edges AWS in Linpack Benchmark Study

February 15, 2017

The “when will clouds be ready for HPC” question has ebbed and flowed for years. Read more…

By John Russell

Is Liquid Cooling Ready to Go Mainstream?

February 13, 2017

Lost in the frenzy of SC16 was a substantial rise in the number of vendors showing server oriented liquid cooling technologies. Three decades ago liquid cooling was pretty much the exclusive realm of the Cray-2 and IBM mainframe class products. That’s changing. We are now seeing an emergence of x86 class server products with exotic plumbing technology ranging from Direct-to-Chip to servers and storage completely immersed in a dielectric fluid. Read more…

By Steve Campbell

For IBM/OpenPOWER: Success in 2017 = (Volume) Sales

January 11, 2017

To a large degree IBM and the OpenPOWER Foundation have done what they said they would – assembling a substantial and growing ecosystem and bringing Power-based products to market, all in about three years. Read more…

By John Russell

US, China Vie for Supercomputing Supremacy

November 14, 2016

The 48th edition of the TOP500 list is fresh off the presses and while there is no new number one system, as previously teased by China, there are a number of notable entrants from the US and around the world and significant trends to report on. Read more…

By Tiffany Trader

Lighting up Aurora: Behind the Scenes at the Creation of the DOE’s Upcoming 200 Petaflops Supercomputer

December 1, 2016

In April 2015, U.S. Department of Energy Undersecretary Franklin Orr announced that Intel would be the prime contractor for Aurora: Read more…

By Jan Rowell

D-Wave SC16 Update: What’s Bo Ewald Saying These Days

November 18, 2016

Tucked in a back section of the SC16 exhibit hall, quantum computing pioneer D-Wave has been talking up its new 2000-qubit processor announced in September. Forget for a moment the criticism sometimes aimed at D-Wave. This small Canadian company has sold several machines including, for example, ones to Lockheed and NASA, and has worked with Google on mapping machine learning problems to quantum computing. In July Los Alamos National Laboratory took possession of a 1000-quibit D-Wave 2X system that LANL ordered a year ago around the time of SC15. Read more…

By John Russell

Enlisting Deep Learning in the War on Cancer

December 7, 2016

Sometime in Q2 2017 the first ‘results’ of the Joint Design of Advanced Computing Solutions for Cancer (JDACS4C) will become publicly available according to Rick Stevens. He leads one of three JDACS4C pilot projects pressing deep learning (DL) into service in the War on Cancer. Read more…

By John Russell

IBM Wants to be “Red Hat” of Deep Learning

January 26, 2017

IBM today announced the addition of TensorFlow and Chainer deep learning frameworks to its PowerAI suite of deep learning tools, which already includes popular offerings such as Caffe, Theano, and Torch. Read more…

By John Russell

HPC Startup Advances Auto-Parallelization’s Promise

January 23, 2017

The shift from single core to multicore hardware has made finding parallelism in codes more important than ever, but that hasn’t made the task of parallel programming any easier. Read more…

By Tiffany Trader

Tokyo Tech’s TSUBAME3.0 Will Be First HPE-SGI Super

February 16, 2017

In a press event Friday afternoon local time in Japan, Tokyo Institute of Technology (Tokyo Tech) announced its plans for the TSUBAME3.0 supercomputer, which will be Japan’s “fastest AI supercomputer,” Read more…

By Tiffany Trader

Leading Solution Providers

CPU Benchmarking: Haswell Versus POWER8

June 2, 2015

With OpenPOWER activity ramping up and IBM’s prominent role in the upcoming DOE machines Summit and Sierra, it’s a good time to look at how the IBM POWER CPU stacks up against the x86 Xeon Haswell CPU from Intel. Read more…

By Tiffany Trader

Nvidia Sees Bright Future for AI Supercomputing

November 23, 2016

Graphics chipmaker Nvidia made a strong showing at SC16 in Salt Lake City last week. Read more…

By Tiffany Trader

BioTeam’s Berman Charts 2017 HPC Trends in Life Sciences

January 4, 2017

Twenty years ago high performance computing was nearly absent from life sciences. Today it’s used throughout life sciences and biomedical research. Genomics and the data deluge from modern lab instruments are the main drivers, but so is the longer-term desire to perform predictive simulation in support of Precision Medicine (PM). There’s even a specialized life sciences supercomputer, ‘Anton’ from D.E. Shaw Research, and the Pittsburgh Supercomputing Center is standing up its second Anton 2 and actively soliciting project proposals. There’s a lot going on. Read more…

By John Russell

TSUBAME3.0 Points to Future HPE Pascal-NVLink-OPA Server

February 17, 2017

Since our initial coverage of the TSUBAME3.0 supercomputer yesterday, more details have come to light on this innovative project. Of particular interest is a new board design for NVLink-equipped Pascal P100 GPUs that will create another entrant to the space currently occupied by Nvidia's DGX-1 system, IBM's "Minsky" platform and the Supermicro SuperServer (1028GQ-TXR). Read more…

By Tiffany Trader

IDG to Be Bought by Chinese Investors; IDC to Spin Out HPC Group

January 19, 2017

US-based publishing and investment firm International Data Group, Inc. (IDG) will be acquired by a pair of Chinese investors, China Oceanwide Holdings Group Co., Ltd. Read more…

By Tiffany Trader

Dell Knights Landing Machine Sets New STAC Records

November 2, 2016

The Securities Technology Analysis Center, commonly known as STAC, has released a new report characterizing the performance of the Knight Landing-based Dell PowerEdge C6320p server on the STAC-A2 benchmarking suite, widely used by the financial services industry to test and evaluate computing platforms. The Dell machine has set new records for both the baseline Greeks benchmark and the large Greeks benchmark. Read more…

By Tiffany Trader

Is Liquid Cooling Ready to Go Mainstream?

February 13, 2017

Lost in the frenzy of SC16 was a substantial rise in the number of vendors showing server oriented liquid cooling technologies. Three decades ago liquid cooling was pretty much the exclusive realm of the Cray-2 and IBM mainframe class products. That’s changing. We are now seeing an emergence of x86 class server products with exotic plumbing technology ranging from Direct-to-Chip to servers and storage completely immersed in a dielectric fluid. Read more…

By Steve Campbell

What Knights Landing Is Not

June 18, 2016

As we get ready to launch the newest member of the Intel Xeon Phi family, code named Knights Landing, it is natural that there be some questions and potentially some confusion. Read more…

By James Reinders, Intel

  • arrow
  • Click Here for More Headlines
  • arrow
Share This