BGI Speeds Genome Analysis with GPUs

By Michael Feldman

December 15, 2011

The data deluge in the life sciences is no where more acute than at Chinese genomics powerhouse BGI, which probably sequences more DNA than any other organization in the world. To turn that data into something meaningful for genomic researchers, the institute has begun to employ GPU-accelerated HPC to greatly reduce processing times. In doing so, BGI was able to increase computational throughput by an order of magnitude or more.

At the GPU Technology Conference in Beijing this week, Dr. BingQiang Wang, who heads the HPC group at BGI, described the daunting task of keeping the computational analysis in line with the rapid accumulation of genomic data. At BGI, he says, they are currently able to sequence 6 trillion base pairs per day and have a stored database totaling 20 PB.

The data deluge problem stems from an imbalance between the DNA sequencing technology and computer technology. According to Dr. Wang, using second-generation sequencing machines, genomes can now be mapped 50,000 times faster than just a decade ago. The technology on track to increase approximately 10-fold every 18 months. That is 5 times the rate of Moore’s Law, and therein lies the problem.

Obviously it would be impractical to upgrade one’s computational infrastructure at that rate, so BGI has turned to NVIDIA GPUs to accelerate the analytics end of the workflow. The architecture of the GPU is particularly suitable for DNA data crunching, thanks to its many simple cores and its high memory bandwidth. Encouraged by the speedup results from similar types of data-parallel programs, BGI developed three genome analysis applications (SOAP3, GSNP, and GAMA) to take advantage of the manycore processing power of the graphics processor.

Developed in 2011, SOAP3 is a GPU-enabled short oligonucleotide alignment program, which aligns short reads against a reference DNA sequence. Thanks to GPU acceleration and some additional memory capacity on the CPU side, SOAP3 is 10 to 30 times faster than its CPU-only predecessor, SOAP2. Running SOAP3 on a Xeon cluster using NVIDIA’s Tesla C2070 module, BGI was able to increase performance by 10X for a human genome — 16X if you discount data loading times from the CPU to the GPU.

The SNP detection tool, GSNP, is GPU-enabled version of SOAPsnp, which find differences of a single nucleotide polymorphism (SNP) in the DNA. SNPs represent genetic variations that can be associated with traits such as disease resistance and drug response. Using GSNP, BGI was able to reduce processing times by about 7X on a typical run — from 4 days to 14 hours.

GAMA is another genetic variation code, used to estimate the frequencies of gene variants. To compute the frequencies of 1,000 individuals, the original version of GAMA could take a year or more. The GPU-accelerated version could do the same in just two days.

Using GPU-accelerated tools, BGI has been able to reduce the computational part of their standard workflow from about 11 days to 23 hours. But data manipulation times for the storage only decreased at a more modest 50 percent. As a result the data manipulation component of the workflow went from 8 percent of the total time to 25 percent.

The solution was data compression, which was accomplished inside the GPU. BGI implements a Hoffman-based compression algorithm that delivers a compression ration of around 24 percent. The compression rate is a respectable 1 GB/second, with decompression at 1.5 GB/second.

Most of the work described here was done on a BGI-owned 20-GPU server cluster, employing NVIDIA Tesla parts. According to Wang, they have two such clusters, one at their main facility in Shenzhen and another at their Hong Kong office. Storage is provided by Isilon and is made up of multiple systems to house their 20 PB (and growing) database.

Although the workhorse HPC clusters are used for the majority of the BGI analysis tools, more challenging genomics requires a great deal more processing power that a 20-GPU machine. For example, BGI has an application that estimates minor allele frequency (MAF) across a population. MAF refers to the frequency at which the less common alleles occurs in a given population. It’s useful for studying genetic variations on a geographical scale.

To estimate the MAF results for even a modest size population is very computationally expensive. For example, using just 1,024 human genomes, it would take 10 years on a single CPU and 0.5 years on a single GPU to generate the MAF results. To make such an application run feasible, one would need thousands or CPUs or hundreds of GPUs.

To achieve an MAF population estimation, BGI teamed up with the Tianjin Supercomputing Center to use their GPU-equipped Tianhe-1A, the top supercomputer in China, and the second most powerful system in the world. Using 256 of the machine’s 7,168 GPUs, and employing MPI to communicate between the nodes, the MAF run for that 1,024 population took just 13 hours.

To date, all of GPU porting effort for the analytics applications has been done under CUDA, requiring some serious development effort on the part of the BGI team. Dr. Wang would like to make the development effort more productive, and is intrigued by the recently announced OpenACC programming model, which would allow developers to insert OpenMP-like directives into non-CUDA serial code to expose the parallelism.

Dr. Wang says the GPU application coding has necessitated both computer engineers with GPU expertise as well as biologists who have an intimate knowledge of the genomics application domain. To develop these kinds of applications, the scientists have to work in tandem. Ideally, a developer would encompass both areas of expertise, says Wang. But, he adds, “there is no such person.”

Subscribe to HPCwire's Weekly Update!

Be the most informed person in the room! Stay ahead of the tech trends with industy updates delivered to you every week!

Weekly Twitter Roundup (Jan. 12, 2017)

January 12, 2017

Here at HPCwire, we aim to keep the HPC community apprised of the most relevant and interesting news items that get tweeted throughout the week. Read more…

By Thomas Ayres

NSF Seeks Input on Cyberinfrastructure Advances Needed

January 12, 2017

In cased you missed it, the National Science Foundation posted a “Dear Colleague Letter” (DCL) late last week seeking input on needs for the next generation of cyberinfrastructure to support science and engineering. Read more…

By John Russell

NSF Approves Bridges Phase 2 Upgrade for Broader Research Use

January 12, 2017

The recently completed phase 2 upgrade of the Bridges supercomputer at the Pittsburgh Supercomputing Center (PSC) has been approved by the National Science Foundation (NSF) making it now available for research allocations to the national scientific community, according to an announcement posted this week on the XSEDE web site. Read more…

By John Russell

Clemson Software Optimizes Big Data Transfers

January 11, 2017

Data-intensive science is not a new phenomenon as the high-energy physics and astrophysics communities can certainly attest, but today more and more scientists are facing steep data and throughput challenges fueled by soaring data volumes and the demands of global-scale collaboration. Read more…

By Tiffany Trader

HPE Extreme Performance Solutions

Remote Visualization: An Integral Technology for Upstream Oil & Gas

As the exploration and production (E&P) of natural resources evolves into an even more complex and vital task, visualization technology has become integral for the upstream oil and gas industry. Read more…

For IBM/OpenPOWER: Success in 2017 = (Volume) Sales

January 11, 2017

To a large degree IBM and the OpenPOWER Foundation have done what they said they would – assembling a substantial and growing ecosystem and bringing Power-based products to market, all in about three years. Read more…

By John Russell

UberCloud Cites Progress in HPC Cloud Computing

January 10, 2017

200 HPC cloud experiments, 80 case studies, and a ton of hands-on experience gained, that’s the harvest of four years of UberCloud HPC Experiments. Read more…

By Wolfgang Gentzsch and Burak Yenier

A Conversation with Women in HPC Director Toni Collis

January 6, 2017

In this SC16 video interview, HPCwire Managing Editor Tiffany Trader sits down with Toni Collis, the director and founder of the Women in HPC (WHPC) network, to discuss the strides made since the organization’s debut in 2014. Read more…

By Tiffany Trader

FPGA-Based Genome Processor Bundles Storage

January 6, 2017

Bio-processor developer Edico Genome is collaborating with storage specialist Dell EMC to bundle computing and storage for analyzing gene-sequencing data. Read more…

By George Leopold

For IBM/OpenPOWER: Success in 2017 = (Volume) Sales

January 11, 2017

To a large degree IBM and the OpenPOWER Foundation have done what they said they would – assembling a substantial and growing ecosystem and bringing Power-based products to market, all in about three years. Read more…

By John Russell

UberCloud Cites Progress in HPC Cloud Computing

January 10, 2017

200 HPC cloud experiments, 80 case studies, and a ton of hands-on experience gained, that’s the harvest of four years of UberCloud HPC Experiments. Read more…

By Wolfgang Gentzsch and Burak Yenier

A Conversation with Women in HPC Director Toni Collis

January 6, 2017

In this SC16 video interview, HPCwire Managing Editor Tiffany Trader sits down with Toni Collis, the director and founder of the Women in HPC (WHPC) network, to discuss the strides made since the organization’s debut in 2014. Read more…

By Tiffany Trader

BioTeam’s Berman Charts 2017 HPC Trends in Life Sciences

January 4, 2017

Twenty years ago high performance computing was nearly absent from life sciences. Today it’s used throughout life sciences and biomedical research. Genomics and the data deluge from modern lab instruments are the main drivers, but so is the longer-term desire to perform predictive simulation in support of Precision Medicine (PM). There’s even a specialized life sciences supercomputer, ‘Anton’ from D.E. Shaw Research, and the Pittsburgh Supercomputing Center is standing up its second Anton 2 and actively soliciting project proposals. There’s a lot going on. Read more…

By John Russell

Fast Rewind: 2016 Was a Wild Ride for HPC

December 23, 2016

Some years quietly sneak by – 2016 not so much. It’s safe to say there are always forces reshaping the HPC landscape but this year’s bunch seemed like a noisy lot. Among the noisemakers: TaihuLight, DGX-1/Pascal, Dell EMC & HPE-SGI et al., KNL to market, OPA-IB chest thumping, Fujitsu-ARM, new U.S. President-elect, BREXIT, JR’s Intel Exit, Exascale (whatever that means now), NCSA@30, whither NSCI, Deep Learning mania, HPC identity crisis…You get the picture. Read more…

By John Russell

AWI Uses New Cray Cluster for Earth Sciences and Bioinformatics

December 22, 2016

The Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research (AWI), headquartered in Bremerhaven, Germany, is one of the country's premier research institutes within the Helmholtz Association of German Research Centres, and is an internationally respected center of expertise for polar and marine research. In November 2015, AWI awarded Cray a contract to install a cluster supercomputer that would help the institute accelerate time to discovery. Now the effort is starting to pay off. Read more…

By Linda Barney

Addison Snell: The ‘Wild West’ of HPC Disaggregation

December 16, 2016

We caught up with Addison Snell, CEO of HPC industry watcher Intersect360, at SC16 last month, and Snell had his expected, extensive list of insights into trends driving advanced-scale technology in both the commercial and research sectors. Read more…

By Doug Black

KNUPATH Hermosa-based Commercial Boards Expected in Q1 2017

December 15, 2016

Last June tech start-up KnuEdge emerged from stealth mode to begin spreading the word about its new processor and fabric technology that’s been roughly a decade in the making. Read more…

By John Russell

AWS Beats Azure to K80 General Availability

September 30, 2016

Amazon Web Services has seeded its cloud with Nvidia Tesla K80 GPUs to meet the growing demand for accelerated computing across an increasingly-diverse range of workloads. The P2 instance family is a welcome addition for compute- and data-focused users who were growing frustrated with the performance limitations of Amazon's G2 instances, which are backed by three-year-old Nvidia GRID K520 graphics cards. Read more…

By Tiffany Trader

US, China Vie for Supercomputing Supremacy

November 14, 2016

The 48th edition of the TOP500 list is fresh off the presses and while there is no new number one system, as previously teased by China, there are a number of notable entrants from the US and around the world and significant trends to report on. Read more…

By Tiffany Trader

Vectors: How the Old Became New Again in Supercomputing

September 26, 2016

Vector instructions, once a powerful performance innovation of supercomputing in the 1970s and 1980s became an obsolete technology in the 1990s. But like the mythical phoenix bird, vector instructions have arisen from the ashes. Here is the history of a technology that went from new to old then back to new. Read more…

By Lynd Stringer

Container App ‘Singularity’ Eases Scientific Computing

October 20, 2016

HPC container platform Singularity is just six months out from its 1.0 release but already is making inroads across the HPC research landscape. It's in use at Lawrence Berkeley National Laboratory (LBNL), where Singularity founder Gregory Kurtzer has worked in the High Performance Computing Services (HPCS) group for 16 years. Read more…

By Tiffany Trader

Dell EMC Engineers Strategy to Democratize HPC

September 29, 2016

The freshly minted Dell EMC division of Dell Technologies is on a mission to take HPC mainstream with a strategy that hinges on engineered solutions, beginning with a focus on three industry verticals: manufacturing, research and life sciences. "Unlike traditional HPC where everybody bought parts, assembled parts and ran the workloads and did iterative engineering, we want folks to focus on time to innovation and let us worry about the infrastructure," said Jim Ganthier, senior vice president, validated solutions organization at Dell EMC Converged Platforms Solution Division. Read more…

By Tiffany Trader

For IBM/OpenPOWER: Success in 2017 = (Volume) Sales

January 11, 2017

To a large degree IBM and the OpenPOWER Foundation have done what they said they would – assembling a substantial and growing ecosystem and bringing Power-based products to market, all in about three years. Read more…

By John Russell

Lighting up Aurora: Behind the Scenes at the Creation of the DOE’s Upcoming 200 Petaflops Supercomputer

December 1, 2016

In April 2015, U.S. Department of Energy Undersecretary Franklin Orr announced that Intel would be the prime contractor for Aurora: Read more…

By Jan Rowell

Enlisting Deep Learning in the War on Cancer

December 7, 2016

Sometime in Q2 2017 the first ‘results’ of the Joint Design of Advanced Computing Solutions for Cancer (JDACS4C) will become publicly available according to Rick Stevens. He leads one of three JDACS4C pilot projects pressing deep learning (DL) into service in the War on Cancer. Read more…

By John Russell

Leading Solution Providers

D-Wave SC16 Update: What’s Bo Ewald Saying These Days

November 18, 2016

Tucked in a back section of the SC16 exhibit hall, quantum computing pioneer D-Wave has been talking up its new 2000-qubit processor announced in September. Forget for a moment the criticism sometimes aimed at D-Wave. This small Canadian company has sold several machines including, for example, ones to Lockheed and NASA, and has worked with Google on mapping machine learning problems to quantum computing. In July Los Alamos National Laboratory took possession of a 1000-quibit D-Wave 2X system that LANL ordered a year ago around the time of SC15. Read more…

By John Russell

CPU Benchmarking: Haswell Versus POWER8

June 2, 2015

With OpenPOWER activity ramping up and IBM’s prominent role in the upcoming DOE machines Summit and Sierra, it’s a good time to look at how the IBM POWER CPU stacks up against the x86 Xeon Haswell CPU from Intel. Read more…

By Tiffany Trader

Nvidia Sees Bright Future for AI Supercomputing

November 23, 2016

Graphics chipmaker Nvidia made a strong showing at SC16 in Salt Lake City last week. Read more…

By Tiffany Trader

New Genomics Pipeline Combines AWS, Local HPC, and Supercomputing

September 22, 2016

Declining DNA sequencing costs and the rush to do whole genome sequencing (WGS) of large cohort populations – think 5000 subjects now, but many more thousands soon – presents a formidable computational challenge to researchers attempting to make sense of large cohort datasets. Read more…

By John Russell

Beyond von Neumann, Neuromorphic Computing Steadily Advances

March 21, 2016

Neuromorphic computing – brain inspired computing – has long been a tantalizing goal. The human brain does with around 20 watts what supercomputers do with megawatts. And power consumption isn’t the only difference. Fundamentally, brains ‘think differently’ than the von Neumann architecture-based computers. While neuromorphic computing progress has been intriguing, it has still not proven very practical. Read more…

By John Russell

The Exascale Computing Project Awards $39.8M to 22 Projects

September 7, 2016

The Department of Energy’s Exascale Computing Project (ECP) hit an important milestone today with the announcement of its first round of funding, moving the nation closer to its goal of reaching capable exascale computing by 2023. Read more…

By Tiffany Trader

Dell Knights Landing Machine Sets New STAC Records

November 2, 2016

The Securities Technology Analysis Center, commonly known as STAC, has released a new report characterizing the performance of the Knight Landing-based Dell PowerEdge C6320p server on the STAC-A2 benchmarking suite, widely used by the financial services industry to test and evaluate computing platforms. The Dell machine has set new records for both the baseline Greeks benchmark and the large Greeks benchmark. Read more…

By Tiffany Trader

Deep Learning Paves Way for Better Diagnostics

September 19, 2016

Stanford researchers are leveraging GPU-based machines in the Amazon EC2 cloud to run deep learning workloads with the goal of improving diagnostics for a chronic eye disease, called diabetic retinopathy. The disease is a complication of diabetes that can lead to blindness if blood sugar is poorly controlled. It affects about 45 percent of diabetics and 100 million people worldwide, many in developing nations. Read more…

By Tiffany Trader

  • arrow
  • Click Here for More Headlines
  • arrow
Share This