The Era of Personalized Medicine: An Interview with Peter Coveney

By Wolfgang Gentzsch and Sverre Jarp

September 3, 2015

What opportunities and challenges come with personalized medicine? What amount of computing is necessary to get meaningful results? Are we able to handle substantial quantities of patient data and to use them to perform predictive, mechanistic modelling and simulation? Based on this, will we be able to deliver therapies and to enhance clinical decision making. Can we guaranty secure access to personal data, as well as to powerful computational resources? Answers to these and other critical questions are discussed in this interview with Professor Peter Coveney who holds a Chair in Physical Chemistry and is Director of the Centre for Computational Science (CCS), an Honorary Professor in Computer Science and a member of CoMPLEX at University College London (UCL). He is also Professor Adjunct within the Medical School at Yale University. Prof. Coveney led the Network of Excellence within the EU FP7 Virtual Physiological Human initiative, which will form part of his keynote lecture on “The Virtual Human: In Silico Methods for Personalized Medicine” at the ISC Cloud & Big Data Conference September 28 – 30 in Frankfurt, Germany.

Peter, thanks for making time for this interview. Please tell us a bit more about one of your major research projects, the Virtual Physiological Human.

Peter Coveney: The Virtual Physiological Human (VPH) is a methodological and technological framework that enables the collaborative investigation of the human body as a single complex system. The collective framework makes it possible to share resources and observations formed by institutions and organisations creating disparate but integrated computer models of the mechanical, physical and biochemical functions of a living human body. As an EU funded initiative, VPH was at its height during Framework Programme 7 (2007-2014), but the agenda is so wide ranging and ambitious that it is something that needs to be pursued throughout the entirety of the twenty-first century.

Can you highlight the great opportunities this research will present over time for us humans?

Coveney: It enables collaborative investigation of the human body across all relevant scales and introduces multiscale methodologies into medical and clinical research, in order to allow greater personalisation of medical treatments. Best summarised by John C. Lechleiter, Ph.D., President and Chief Executive Officer, Eli Lilly and Company: “The power in tailored therapeutics is for us to say more clearly to payers, providers, and patients, — ‘this drug is not for everyone, but it is for you’ — that is exceedingly powerful.”

And what are the major challenges you and your team are currently facing, and which additional challenges do you see arising in a few years?

Coveney: There is the need for rapid development of computational science and informatics capabilities to deal with management and analysis of data. Major challenges relate to the acquisition and storage of personal medical data, and accessing security HPC facilities to process the data.

Where do you anticipate resistance from the general public and the politicians?

Peter Coveney: The sharing and use of personal medical data and the potential efficacy of treatments selected by computer.

Can you give us an example of the amount of computing and data analysis necessary to make this project a success?

Coveney: For an instance of patient specific drug treatment, as applied to a single individual, we would require of the order of 200,000 core hours with 5 terabytes of data being generated and analysed in the process of ranking the drugs concerned. This is of course in addition to all the data and processing needed to obtain the genomic data originally (again this would amount to terabytes of data and many tens of thousands core hours with current so-called “next generation sequencing” technologies). Needless to say, the answer is a moving target inasmuch as both compute and sequencing technologies are perpetually evolving and are likely to reduce dramatically over the next 5-10 year period.

This interview with Professor Peter Coveney has been conducted by Wolfgang Gentzsch and Sverre Jarp, the co-chairs of the ISC Cloud & Big Data Conference, taking place this year in Frankfurt, September 28 – 30. Prof. Coveney will explore these topics in greater detail during his keynote presentation.

Subscribe to HPCwire's Weekly Update!

Be the most informed person in the room! Stay ahead of the tech trends with industy updates delivered to you every week!

First All-Petaflops Top500 List Debuts; US Maintains Performance Lead

June 17, 2019

With the kick-off of the International Supercomputing Conference (ISC) in Frankfurt this morning, the 53rd Top500 list made its debut, and this one's for petafloppers only. The entry point for the new list is 1.022 petaf Read more…

By Tiffany Trader

Nvidia Embraces Arm, Declares Intent to Accelerate All CPU Architectures

June 17, 2019

As the Top500 list was being announced at ISC in Frankfurt today with an upgraded petascale Arm supercomputer in the top third of the list, Nvidia announced its intention to make Arm a full citizen in the processing arch Read more…

By Tiffany Trader

Jack Wells Joins OpenACC; Arm Support Coming

June 17, 2019

Perhaps the most significant ISC19 news for OpenACC wasn’t in its official press release yesterday which touted growing user traction and the notable addition of HPC leader Jack Wells, director of science, Oak Ridge Le Read more…

By John Russell

HPE Extreme Performance Solutions

HPE and Intel® Omni-Path Architecture: How to Power a Cloud

Learn how HPE and Intel® Omni-Path Architecture provide critical infrastructure for leading Nordic HPC provider’s HPCFLOW cloud service.

For decades, HPE has been at the forefront of high-performance computing, and we’ve powered some of the fastest and most robust supercomputers in the world. Read more…

IBM Accelerated Insights

5 Benefits Artificial Intelligence Brings to HPC

According to findings from Hyperion Research, simulation is primarily responsible for expanding the global HPC market from $2 billion in 1990 to a projected $38 billion in 2022. Read more…

At ISC: DDN Launches EXA5 for AI, Big Data, HPC Workloads

June 17, 2019

DDN, for two decades competing at the headwaters of high performance storage, this morning announced an enterprise-oriented end-to-end high performance storage and data management for AI, big data and HPC acceleration. I Read more…

By Doug Black

First All-Petaflops Top500 List Debuts; US Maintains Performance Lead

June 17, 2019

With the kick-off of the International Supercomputing Conference (ISC) in Frankfurt this morning, the 53rd Top500 list made its debut, and this one's for petafl Read more…

By Tiffany Trader

Nvidia Embraces Arm, Declares Intent to Accelerate All CPU Architectures

June 17, 2019

As the Top500 list was being announced at ISC in Frankfurt today with an upgraded petascale Arm supercomputer in the top third of the list, Nvidia announced its Read more…

By Tiffany Trader

Jack Wells Joins OpenACC; Arm Support Coming

June 17, 2019

Perhaps the most significant ISC19 news for OpenACC wasn’t in its official press release yesterday which touted growing user traction and the notable addition Read more…

By John Russell

At ISC: DDN Launches EXA5 for AI, Big Data, HPC Workloads

June 17, 2019

DDN, for two decades competing at the headwaters of high performance storage, this morning announced an enterprise-oriented end-to-end high performance storage Read more…

By Doug Black

Final Countdown to ISC19: What to See

June 13, 2019

If you're attending the International Supercomputing Conference, taking place in Frankfurt next week (June 16-20), you're either packing, in transit, or are alr Read more…

By Tiffany Trader

The US Global Weather Forecast System Just Got a Major Upgrade

June 13, 2019

The United States’ Global Forecast System (GFS) has received a major upgrade to its modeling capabilities. The new dynamical core that has been added to the G Read more…

By Oliver Peckham

TSMC and Samsung Moving to 5nm; Whither Moore’s Law?

June 12, 2019

With reports that Taiwan Semiconductor Manufacturing Co. (TMSC) and Samsung are moving quickly to 5nm manufacturing, it’s a good time to again ponder whither goes the venerable Moore’s law. Shrinking feature size has of course been the primary hallmark of achieving Moore’s law... Read more…

By John Russell

The Spaceborne Computer Returns to Earth, and HPE Eyes an AI-Protected Spaceborne 2

June 10, 2019

After 615 days on the International Space Station (ISS), HPE’s Spaceborne Computer has returned to Earth. The computer touched down onboard the same SpaceX Dr Read more…

By Oliver Peckham

High Performance (Potato) Chips

May 5, 2006

In this article, we focus on how Procter & Gamble is using high performance computing to create some common, everyday supermarket products. Tom Lange, a 27-year veteran of the company, tells us how P&G models products, processes and production systems for the betterment of consumer package goods. Read more…

By Michael Feldman

Cray, AMD to Extend DOE’s Exascale Frontier

May 7, 2019

Cray and AMD are coming back to Oak Ridge National Laboratory to partner on the world’s largest and most expensive supercomputer. The Department of Energy’s Read more…

By Tiffany Trader

Graphene Surprises Again, This Time for Quantum Computing

May 8, 2019

Graphene is fascinating stuff with promise for use in a seeming endless number of applications. This month researchers from the University of Vienna and Institu Read more…

By John Russell

Why Nvidia Bought Mellanox: ‘Future Datacenters Will Be…Like High Performance Computers’

March 14, 2019

“Future datacenters of all kinds will be built like high performance computers,” said Nvidia CEO Jensen Huang during a phone briefing on Monday after Nvidia revealed scooping up the high performance networking company Mellanox for $6.9 billion. Read more…

By Tiffany Trader

AMD Verifies Its Largest 7nm Chip Design in Ten Hours

June 5, 2019

AMD announced last week that its engineers had successfully executed the first physical verification of its largest 7nm chip design – in just ten hours. The AMD Radeon Instinct Vega20 – which boasts 13.2 billion transistors – was tested using a TSMC-certified Calibre nmDRC software platform from Mentor. Read more…

By Oliver Peckham

It’s Official: Aurora on Track to Be First US Exascale Computer in 2021

March 18, 2019

The U.S. Department of Energy along with Intel and Cray confirmed today that an Intel/Cray supercomputer, "Aurora," capable of sustained performance of one exaf Read more…

By Tiffany Trader

Deep Learning Competitors Stalk Nvidia

May 14, 2019

There is no shortage of processing architectures emerging to accelerate deep learning workloads, with two more options emerging this week to challenge GPU leader Nvidia. First, Intel researchers claimed a new deep learning record for image classification on the ResNet-50 convolutional neural network. Separately, Israeli AI chip startup Hailo.ai... Read more…

By George Leopold

The Case Against ‘The Case Against Quantum Computing’

January 9, 2019

It’s not easy to be a physicist. Richard Feynman (basically the Jimi Hendrix of physicists) once said: “The first principle is that you must not fool yourse Read more…

By Ben Criger

Leading Solution Providers

SC 18 Virtual Booth Video Tour

Advania @ SC18 AMD @ SC18
ASRock Rack @ SC18
DDN Storage @ SC18
HPE @ SC18
IBM @ SC18
Lenovo @ SC18 Mellanox Technologies @ SC18
NVIDIA @ SC18
One Stop Systems @ SC18
Oracle @ SC18 Panasas @ SC18
Supermicro @ SC18 SUSE @ SC18 TYAN @ SC18
Verne Global @ SC18

TSMC and Samsung Moving to 5nm; Whither Moore’s Law?

June 12, 2019

With reports that Taiwan Semiconductor Manufacturing Co. (TMSC) and Samsung are moving quickly to 5nm manufacturing, it’s a good time to again ponder whither goes the venerable Moore’s law. Shrinking feature size has of course been the primary hallmark of achieving Moore’s law... Read more…

By John Russell

Intel Launches Cascade Lake Xeons with Up to 56 Cores

April 2, 2019

At Intel's Data-Centric Innovation Day in San Francisco (April 2), the company unveiled its second-generation Xeon Scalable (Cascade Lake) family and debuted it Read more…

By Tiffany Trader

Cray – and the Cray Brand – to Be Positioned at Tip of HPE’s HPC Spear

May 22, 2019

More so than with most acquisitions of this kind, HPE’s purchase of Cray for $1.3 billion, announced last week, seems to have elements of that overused, often Read more…

By Doug Black and Tiffany Trader

Arm Unveils Neoverse N1 Platform with up to 128-Cores

February 20, 2019

Following on its Neoverse roadmap announcement last October, Arm today revealed its next-gen Neoverse microarchitecture with compute and throughput-optimized si Read more…

By Tiffany Trader

Announcing four new HPC capabilities in Google Cloud Platform

April 15, 2019

When you’re running compute-bound or memory-bound applications for high performance computing or large, data-dependent machine learning training workloads on Read more…

By Wyatt Gorman, HPC Specialist, Google Cloud; Brad Calder, VP of Engineering, Google Cloud; Bart Sano, VP of Platforms, Google Cloud

Nvidia Embraces Arm, Declares Intent to Accelerate All CPU Architectures

June 17, 2019

As the Top500 list was being announced at ISC in Frankfurt today with an upgraded petascale Arm supercomputer in the top third of the list, Nvidia announced its Read more…

By Tiffany Trader

In Wake of Nvidia-Mellanox: Xilinx to Acquire Solarflare

April 25, 2019

With echoes of Nvidia’s recent acquisition of Mellanox, FPGA maker Xilinx has announced a definitive agreement to acquire Solarflare Communications, provider Read more…

By Doug Black

Nvidia Claims 6000x Speed-Up for Stock Trading Backtest Benchmark

May 13, 2019

A stock trading backtesting algorithm used by hedge funds to simulate trading variants has received a massive, GPU-based performance boost, according to Nvidia, Read more…

By Doug Black

  • arrow
  • Click Here for More Headlines
  • arrow
Do NOT follow this link or you will be banned from the site!
Share This