The Era of Personalized Medicine: An Interview with Peter Coveney

By Wolfgang Gentzsch and Sverre Jarp

September 3, 2015

What opportunities and challenges come with personalized medicine? What amount of computing is necessary to get meaningful results? Are we able to handle substantial quantities of patient data and to use them to perform predictive, mechanistic modelling and simulation? Based on this, will we be able to deliver therapies and to enhance clinical decision making. Can we guaranty secure access to personal data, as well as to powerful computational resources? Answers to these and other critical questions are discussed in this interview with Professor Peter Coveney who holds a Chair in Physical Chemistry and is Director of the Centre for Computational Science (CCS), an Honorary Professor in Computer Science and a member of CoMPLEX at University College London (UCL). He is also Professor Adjunct within the Medical School at Yale University. Prof. Coveney led the Network of Excellence within the EU FP7 Virtual Physiological Human initiative, which will form part of his keynote lecture on “The Virtual Human: In Silico Methods for Personalized Medicine” at the ISC Cloud & Big Data Conference September 28 – 30 in Frankfurt, Germany.

Peter, thanks for making time for this interview. Please tell us a bit more about one of your major research projects, the Virtual Physiological Human.

Peter Coveney: The Virtual Physiological Human (VPH) is a methodological and technological framework that enables the collaborative investigation of the human body as a single complex system. The collective framework makes it possible to share resources and observations formed by institutions and organisations creating disparate but integrated computer models of the mechanical, physical and biochemical functions of a living human body. As an EU funded initiative, VPH was at its height during Framework Programme 7 (2007-2014), but the agenda is so wide ranging and ambitious that it is something that needs to be pursued throughout the entirety of the twenty-first century.

Can you highlight the great opportunities this research will present over time for us humans?

Coveney: It enables collaborative investigation of the human body across all relevant scales and introduces multiscale methodologies into medical and clinical research, in order to allow greater personalisation of medical treatments. Best summarised by John C. Lechleiter, Ph.D., President and Chief Executive Officer, Eli Lilly and Company: “The power in tailored therapeutics is for us to say more clearly to payers, providers, and patients, — ‘this drug is not for everyone, but it is for you’ — that is exceedingly powerful.”

And what are the major challenges you and your team are currently facing, and which additional challenges do you see arising in a few years?

Coveney: There is the need for rapid development of computational science and informatics capabilities to deal with management and analysis of data. Major challenges relate to the acquisition and storage of personal medical data, and accessing security HPC facilities to process the data.

Where do you anticipate resistance from the general public and the politicians?

Peter Coveney: The sharing and use of personal medical data and the potential efficacy of treatments selected by computer.

Can you give us an example of the amount of computing and data analysis necessary to make this project a success?

Coveney: For an instance of patient specific drug treatment, as applied to a single individual, we would require of the order of 200,000 core hours with 5 terabytes of data being generated and analysed in the process of ranking the drugs concerned. This is of course in addition to all the data and processing needed to obtain the genomic data originally (again this would amount to terabytes of data and many tens of thousands core hours with current so-called “next generation sequencing” technologies). Needless to say, the answer is a moving target inasmuch as both compute and sequencing technologies are perpetually evolving and are likely to reduce dramatically over the next 5-10 year period.

This interview with Professor Peter Coveney has been conducted by Wolfgang Gentzsch and Sverre Jarp, the co-chairs of the ISC Cloud & Big Data Conference, taking place this year in Frankfurt, September 28 – 30. Prof. Coveney will explore these topics in greater detail during his keynote presentation.

Subscribe to HPCwire's Weekly Update!

Be the most informed person in the room! Stay ahead of the tech trends with industy updates delivered to you every week!

Google Cloud Makes Good on Promise to Add Nvidia P100 GPUs

September 21, 2017

Google has taken down the notice on its cloud platform website that says Nvidia Tesla P100s are “coming soon.” That's because the search giant has announced the beta launch of the high-end P100 Nvidia Tesla GPUs on t Read more…

By George Leopold

Cray Wins $48M Supercomputer Contract from KISTI

September 21, 2017

It was a good day for Cray which won a $48 million contract from the Korea Institute of Science and Technology Information (KISTI) for a 128-rack CS500 cluster supercomputer. The new system, equipped with Intel Xeon Scal Read more…

By John Russell

Adolfy Hoisie to Lead Brookhaven’s Computing for National Security Effort

September 21, 2017

Brookhaven National Laboratory announced today that Adolfy Hoisie will chair its newly formed Computing for National Security department, which is part of Brookhaven’s new Computational Science Initiative (CSI). Read more…

By John Russell

HPE Extreme Performance Solutions

HPE Prepares Customers for Success with the HPC Software Portfolio

High performance computing (HPC) software is key to harnessing the full power of HPC environments. Development and management tools enable IT departments to streamline installation and maintenance of their systems as well as create, optimize, and run their HPC applications. Read more…

PNNL’s Center for Advanced Tech Evaluation Seeks Wider HPC Community Ties

September 21, 2017

Two years ago the Department of Energy established the Center for Advanced Technology Evaluation (CENATE) at Pacific Northwest National Laboratory (PNNL). CENATE’s ambitious mission was to be a proving ground for near- Read more…

By John Russell

Stanford University and UberCloud Achieve Breakthrough in Living Heart Simulations

September 21, 2017

Cardiac arrhythmia can be an undesirable and potentially lethal side effect of drugs. During this condition, the electrical activity of the heart turns chaotic, Read more…

By Wolfgang Gentzsch, UberCloud, and Francisco Sahli, Stanford University

PNNL’s Center for Advanced Tech Evaluation Seeks Wider HPC Community Ties

September 21, 2017

Two years ago the Department of Energy established the Center for Advanced Technology Evaluation (CENATE) at Pacific Northwest National Laboratory (PNNL). CENAT Read more…

By John Russell

Exascale Computing Project Names Doug Kothe as Director

September 20, 2017

The Department of Energy’s Exascale Computing Project (ECP) has named Doug Kothe as its new director effective October 1. He replaces Paul Messina, who is s Read more…

Takeaways from the Milwaukee HPC User Forum

September 19, 2017

Milwaukee’s elegant Pfister Hotel hosted approximately 100 attendees for the 66th HPC User Forum (September 5-7, 2017). In the original home city of Pabst Blu Read more…

By Merle Giles

Kathy Yelick Charts the Promise and Progress of Exascale Science

September 15, 2017

On Friday, Sept. 8, Kathy Yelick of Lawrence Berkeley National Laboratory and the University of California, Berkeley, delivered the keynote address on “Breakt Read more…

By Tiffany Trader

DARPA Pledges Another $300 Million for Post-Moore’s Readiness

September 14, 2017

The Defense Advanced Research Projects Agency (DARPA) launched a giant funding effort to ensure the United States can sustain the pace of electronic innovation vital to both a flourishing economy and a secure military. Under the banner of the Electronics Resurgence Initiative (ERI), some $500-$800 million will be invested in post-Moore’s Law technologies. Read more…

By Tiffany Trader

IBM Breaks Ground for Complex Quantum Chemistry

September 14, 2017

IBM has reported the use of a novel algorithm to simulate BeH2 (beryllium-hydride) on a quantum computer. This is the largest molecule so far simulated on a quantum computer. The technique, which used six qubits of a seven-qubit system, is an important step forward and may suggest an approach to simulating ever larger molecules. Read more…

By John Russell

Cubes, Culture, and a New Challenge: Trish Damkroger Talks about Life at Intel—and Why HPC Matters More Than Ever

September 13, 2017

Trish Damkroger wasn’t looking to change jobs when she attended SC15 in Austin, Texas. Capping a 15-year career within Department of Energy (DOE) laboratories, she was acting Associate Director for Computation at Lawrence Livermore National Laboratory (LLNL). Her mission was to equip the lab’s scientists and research partners with resources that would advance their cutting-edge work... Read more…

By Jan Rowell

How ‘Knights Mill’ Gets Its Deep Learning Flops

June 22, 2017

Intel, the subject of much speculation regarding the delayed, rewritten or potentially canceled “Aurora” contract (the Argonne Lab part of the CORAL “ Read more…

By Tiffany Trader

Reinders: “AVX-512 May Be a Hidden Gem” in Intel Xeon Scalable Processors

June 29, 2017

Imagine if we could use vector processing on something other than just floating point problems.  Today, GPUs and CPUs work tirelessly to accelerate algorithms Read more…

By James Reinders

NERSC Scales Scientific Deep Learning to 15 Petaflops

August 28, 2017

A collaborative effort between Intel, NERSC and Stanford has delivered the first 15-petaflops deep learning software running on HPC platforms and is, according Read more…

By Rob Farber

Russian Researchers Claim First Quantum-Safe Blockchain

May 25, 2017

The Russian Quantum Center today announced it has overcome the threat of quantum cryptography by creating the first quantum-safe blockchain, securing cryptocurrencies like Bitcoin, along with classified government communications and other sensitive digital transfers. Read more…

By Doug Black

Oracle Layoffs Reportedly Hit SPARC and Solaris Hard

September 7, 2017

Oracle’s latest layoffs have many wondering if this is the end of the line for the SPARC processor and Solaris OS development. As reported by multiple sources Read more…

By John Russell

Six Exascale PathForward Vendors Selected; DoE Providing $258M

June 15, 2017

The much-anticipated PathForward awards for hardware R&D in support of the Exascale Computing Project were announced today with six vendors selected – AMD Read more…

By John Russell

Google Debuts TPU v2 and will Add to Google Cloud

May 25, 2017

Not long after stirring attention in the deep learning/AI community by revealing the details of its Tensor Processing Unit (TPU), Google last week announced the Read more…

By John Russell

Top500 Results: Latest List Trends and What’s in Store

June 19, 2017

Greetings from Frankfurt and the 2017 International Supercomputing Conference where the latest Top500 list has just been revealed. Although there were no major Read more…

By Tiffany Trader

Leading Solution Providers

IBM Clears Path to 5nm with Silicon Nanosheets

June 5, 2017

Two years since announcing the industry’s first 7nm node test chip, IBM and its research alliance partners GlobalFoundries and Samsung have developed a proces Read more…

By Tiffany Trader

Nvidia Responds to Google TPU Benchmarking

April 10, 2017

Nvidia highlights strengths of its newest GPU silicon in response to Google's report on the performance and energy advantages of its custom tensor processor. Read more…

By Tiffany Trader

Graphcore Readies Launch of 16nm Colossus-IPU Chip

July 20, 2017

A second $30 million funding round for U.K. AI chip developer Graphcore sets up the company to go to market with its “intelligent processing unit” (IPU) in Read more…

By Tiffany Trader

Google Releases Deeplearn.js to Further Democratize Machine Learning

August 17, 2017

Spreading the use of machine learning tools is one of the goals of Google’s PAIR (People + AI Research) initiative, which was introduced in early July. Last w Read more…

By John Russell

EU Funds 20 Million Euro ARM+FPGA Exascale Project

September 7, 2017

At the Barcelona Supercomputer Centre on Wednesday (Sept. 6), 16 partners gathered to launch the EuroEXA project, which invests €20 million over three-and-a-half years into exascale-focused research and development. Led by the Horizon 2020 program, EuroEXA picks up the banner of a triad of partner projects — ExaNeSt, EcoScale and ExaNoDe — building on their work... Read more…

By Tiffany Trader

Amazon Debuts New AMD-based GPU Instances for Graphics Acceleration

September 12, 2017

Last week Amazon Web Services (AWS) streaming service, AppStream 2.0, introduced a new GPU instance called Graphics Design intended to accelerate graphics. The Read more…

By John Russell

Cray Moves to Acquire the Seagate ClusterStor Line

July 28, 2017

This week Cray announced that it is picking up Seagate's ClusterStor HPC storage array business for an undisclosed sum. "In short we're effectively transitioning the bulk of the ClusterStor product line to Cray," said CEO Peter Ungaro. Read more…

By Tiffany Trader

IBM Advances Web-based Quantum Programming

September 5, 2017

IBM Research is pairing its Jupyter-based Data Science Experience notebook environment with its cloud-based quantum computer, IBM Q, in hopes of encouraging a new class of entrepreneurial user to solve intractable problems that even exceed the capabilities of the best AI systems. Read more…

By Alex Woodie

  • arrow
  • Click Here for More Headlines
  • arrow
Share This