Researchers Use DNA to Store and Retrieve Digital Movie

By John Russell

July 18, 2017

From abacus to pencil and paper to semiconductor chips, the technology of computing has always been an ever-changing target. The human brain is probably the computer we use most (hopefully) and understand least. This month in Nature, a group of distinguished DNA researchers report storing and then retrieving a digital movie, a rather famous one at that, in DNA.

Using a DNA editing technique borrowed from nature (CRISPR-Cas), the researchers developed a code for pixels depicting shades of gray using the DNA’s four letters, converted the images, frame by frame, into that code, and coaxed the CRISPR editing machinery to insert the coded DNA into bacteria who did what bacteria do – replicate. The researchers then extracted DNA from the growing population of bacteria, sequenced the newly-generated DNA, decoded it, and reproduced the film clip.

Their paper – “CRISPR–Cas encoding of a digital movie into the genomes of a population of living bacteria” – is fascinating on many levels. Not only did the researchers succeed in storing the images in reproducing bacteria, they also uncovered more details of the CRISPR process including ferreting out efficiency factors, and pointed, however distantly, to prospects for a bacteria-DNA-based recording system that mighty be used as a “black box flight recorder” for cells.

There are several good accounts of the work including one in The New York Times (Who Needs Hard Drives? Scientists Store Film Clip in DNA written by Gina Kolata) and another from the National Institutes of Health (Scientists replay movie encoded in DNA). The researchers started working with an image of the hand and progressed to capturing the 1878 film by British photographer Eadweard Muybridge showing horses do indeed take flight, briefly, when running and all the hooves are aloft.

 

The researchers – Seth L. ShipmanJeff NivalaJeffrey D. Macklis, and George M. Church – are all from Harvard and very familiar to the genomics research community. In the paper they understandably concentrate on the CRISPR technology, which is widely being researched, rather than on applications. That said the NYT article notes:

“When something goes wrong, when a person gets ill, doctors might extract the bacteria and play back the record. It would be, said Dr. Church, analogous to the black boxes carried by airplanes whose data is used in the event of a crash.

At the moment, all that is “the other side of science fiction,” said Ewan Birney, director of the European Bioinformatics Institute and a member of the group that put Shakespeare’s sonnets in DNA. “Storing information in DNA is this side of science fiction.” Also in the NYT Article, Birney said, “People’s intuition is tremendously poor about just how small DNA molecules are and how much information can be packed into them.”

Storing information in DNA isn’t new. (That’s sort of what it does without regard to traditional computing technology.) It has been used to store computer data (zeros and ones) and even used for certain massively parallel computations before now. Indeed, researchers had already used the CRISPR system to store sequences in bacteria.

The new work yet another step forward. A good encapsulation of the work is provided in the paper’s abstract, excerpted below.

“DNA is an excellent medium for archiving data. Recent efforts have illustrated the potential for information storage in DNA using synthesized oligonucleotides assembled in vitro. A relatively unexplored avenue of information storage in DNA is the ability to write information into the genome of a living cell by the addition of nucleotides over time. Using the Cas1–Cas2 integrase, the CRISPR–Cas microbial immune system stores the nucleotide content of invading viruses to confer adaptive immunity. When harnessed, this system has the potential to write arbitrary information into the genome. Here we use the CRISPR–Cas system to encode the pixel values of black and white images and a short movie into the genomes of a population of living bacteria. In doing so, we push the technical limits of this information storage system and optimize strategies to minimize those limitations.”

Link to New York Times article: https://www.nytimes.com/2017/07/12/science/film-clip-stored-in-dna.html?_r=0

Link to NIH account: https://www.nih.gov/news-events/news-releases/scientists-replay-movie-encoded-dna

Link to video: https://www.youtube.com/watch?v=gK3dcjBaJyo

Subscribe to HPCwire's Weekly Update!

Be the most informed person in the room! Stay ahead of the tech trends with industy updates delivered to you every week!

GTC 2019: Chief Scientist Bill Dally Provides Glimpse into Nvidia Research Engine

March 22, 2019

Amid the frenzy of GTC this week – Nvidia’s annual conference showcasing all things GPU (and now AI) – William Dally, chief scientist and SVP of research, provided a brief but insightful portrait of Nvidia’s rese Read more…

By John Russell

ORNL Helps Identify Challenges of Extremely Heterogeneous Architectures

March 21, 2019

Exponential growth in classical computing over the last two decades has produced hardware and software that support lightning-fast processing speeds, but advancements are topping out as computing architectures reach thei Read more…

By Laurie Varma

Interview with 2019 Person to Watch Jim Keller

March 21, 2019

On the heels of Intel's reaffirmation that it will deliver the first U.S. exascale computer in 2021, which will feature the company's new Intel Xe architecture, we bring you our interview with our 2019 Person to Watch Jim Keller, head of the Silicon Engineering Group at Intel. Read more…

By HPCwire Editorial Team

HPE Extreme Performance Solutions

HPE and Intel® Omni-Path Architecture: How to Power a Cloud

Learn how HPE and Intel® Omni-Path Architecture provide critical infrastructure for leading Nordic HPC provider’s HPCFLOW cloud service.

powercloud_blog.jpgFor decades, HPE has been at the forefront of high-performance computing, and we’ve powered some of the fastest and most robust supercomputers in the world. Read more…

IBM Accelerated Insights

Insurance: Where’s the Risk?

Insurers are facing extreme competitive challenges in their core businesses. Property and Casualty (P&C) and Life and Health (L&H) firms alike are highly impacted by the ongoing globalization, increasing regulation, and digital transformation of their client bases. Read more…

What’s New in HPC Research: TensorFlow, Buddy Compression, Intel Optane & More

March 20, 2019

In this bimonthly feature, HPCwire highlights newly published research in the high-performance computing community and related domains. From parallel programming to exascale to quantum computing, the details are here. Read more…

By Oliver Peckham

GTC 2019: Chief Scientist Bill Dally Provides Glimpse into Nvidia Research Engine

March 22, 2019

Amid the frenzy of GTC this week – Nvidia’s annual conference showcasing all things GPU (and now AI) – William Dally, chief scientist and SVP of research, Read more…

By John Russell

At GTC: Nvidia Expands Scope of Its AI and Datacenter Ecosystem

March 19, 2019

In the high-stakes race to provide the AI life-cycle solution of choice, three of the biggest horses in the field are IBM, Intel and Nvidia. While the latter is only a fraction of the size of its two bigger rivals, and has been in business for only a fraction of the time, Nvidia continues to impress with an expanding array of new GPU-based hardware, software, robotics, partnerships and... Read more…

By Doug Black

Nvidia Debuts Clara AI Toolkit with Pre-Trained Models for Radiology Use

March 19, 2019

AI’s push into healthcare got a boost yesterday with Nvidia’s release of the Clara Deploy AI toolkit which includes 13 pre-trained models for use in radiolo Read more…

By John Russell

It’s Official: Aurora on Track to Be First US Exascale Computer in 2021

March 18, 2019

The U.S. Department of Energy along with Intel and Cray confirmed today that an Intel/Cray supercomputer, "Aurora," capable of sustained performance of one exaf Read more…

By Tiffany Trader

Why Nvidia Bought Mellanox: ‘Future Datacenters Will Be…Like High Performance Computers’

March 14, 2019

“Future datacenters of all kinds will be built like high performance computers,” said Nvidia CEO Jensen Huang during a phone briefing on Monday after Nvidia revealed scooping up the high performance networking company Mellanox for $6.9 billion. Read more…

By Tiffany Trader

Oil and Gas Supercloud Clears Out Remaining Knights Landing Inventory: All 38,000 Wafers

March 13, 2019

The McCloud HPC service being built by Australia’s DownUnder GeoSolutions (DUG) outside Houston is set to become the largest oil and gas cloud in the world th Read more…

By Tiffany Trader

Quick Take: Trump’s 2020 Budget Spares DoE-funded HPC but Slams NSF and NIH

March 12, 2019

U.S. President Donald Trump’s 2020 budget request, released yesterday, proposes deep cuts in many science programs but seems to spare HPC funding by the Depar Read more…

By John Russell

Nvidia Wins Mellanox Stakes for $6.9 Billion

March 11, 2019

The long-rumored acquisition of Mellanox came to fruition this morning with GPU chipmaker Nvidia’s announcement that it has purchased the high-performance net Read more…

By Doug Black

Quantum Computing Will Never Work

November 27, 2018

Amid the gush of money and enthusiastic predictions being thrown at quantum computing comes a proposed cold shower in the form of an essay by physicist Mikhail Read more…

By John Russell

The Case Against ‘The Case Against Quantum Computing’

January 9, 2019

It’s not easy to be a physicist. Richard Feynman (basically the Jimi Hendrix of physicists) once said: “The first principle is that you must not fool yourse Read more…

By Ben Criger

ClusterVision in Bankruptcy, Fate Uncertain

February 13, 2019

ClusterVision, European HPC specialists that have built and installed over 20 Top500-ranked systems in their nearly 17-year history, appear to be in the midst o Read more…

By Tiffany Trader

Why Nvidia Bought Mellanox: ‘Future Datacenters Will Be…Like High Performance Computers’

March 14, 2019

“Future datacenters of all kinds will be built like high performance computers,” said Nvidia CEO Jensen Huang during a phone briefing on Monday after Nvidia revealed scooping up the high performance networking company Mellanox for $6.9 billion. Read more…

By Tiffany Trader

Intel Reportedly in $6B Bid for Mellanox

January 30, 2019

The latest rumors and reports around an acquisition of Mellanox focus on Intel, which has reportedly offered a $6 billion bid for the high performance interconn Read more…

By Doug Black

Looking for Light Reading? NSF-backed ‘Comic Books’ Tackle Quantum Computing

January 28, 2019

Still baffled by quantum computing? How about turning to comic books (graphic novels for the well-read among you) for some clarity and a little humor on QC. The Read more…

By John Russell

Contract Signed for New Finnish Supercomputer

December 13, 2018

After the official contract signing yesterday, configuration details were made public for the new BullSequana system that the Finnish IT Center for Science (CSC Read more…

By Tiffany Trader

It’s Official: Aurora on Track to Be First US Exascale Computer in 2021

March 18, 2019

The U.S. Department of Energy along with Intel and Cray confirmed today that an Intel/Cray supercomputer, "Aurora," capable of sustained performance of one exaf Read more…

By Tiffany Trader

Leading Solution Providers

SC 18 Virtual Booth Video Tour

Advania @ SC18 AMD @ SC18
ASRock Rack @ SC18
DDN Storage @ SC18
HPE @ SC18
IBM @ SC18
Lenovo @ SC18 Mellanox Technologies @ SC18
NVIDIA @ SC18
One Stop Systems @ SC18
Oracle @ SC18 Panasas @ SC18
Supermicro @ SC18 SUSE @ SC18 TYAN @ SC18
Verne Global @ SC18

Deep500: ETH Researchers Introduce New Deep Learning Benchmark for HPC

February 5, 2019

ETH researchers have developed a new deep learning benchmarking environment – Deep500 – they say is “the first distributed and reproducible benchmarking s Read more…

By John Russell

IBM Quantum Update: Q System One Launch, New Collaborators, and QC Center Plans

January 10, 2019

IBM made three significant quantum computing announcements at CES this week. One was introduction of IBM Q System One; it’s really the integration of IBM’s Read more…

By John Russell

IBM Bets $2B Seeking 1000X AI Hardware Performance Boost

February 7, 2019

For now, AI systems are mostly machine learning-based and “narrow” – powerful as they are by today's standards, they're limited to performing a few, narro Read more…

By Doug Black

The Deep500 – Researchers Tackle an HPC Benchmark for Deep Learning

January 7, 2019

How do you know if an HPC system, particularly a larger-scale system, is well-suited for deep learning workloads? Today, that’s not an easy question to answer Read more…

By John Russell

HPC Reflections and (Mostly Hopeful) Predictions

December 19, 2018

So much ‘spaghetti’ gets tossed on walls by the technology community (vendors and researchers) to see what sticks that it is often difficult to peer through Read more…

By John Russell

Arm Unveils Neoverse N1 Platform with up to 128-Cores

February 20, 2019

Following on its Neoverse roadmap announcement last October, Arm today revealed its next-gen Neoverse microarchitecture with compute and throughput-optimized si Read more…

By Tiffany Trader

Move Over Lustre & Spectrum Scale – Here Comes BeeGFS?

November 26, 2018

Is BeeGFS – the parallel file system with European roots – on a path to compete with Lustre and Spectrum Scale worldwide in HPC environments? Frank Herold Read more…

By John Russell

France to Deploy AI-Focused Supercomputer: Jean Zay

January 22, 2019

HPE announced today that it won the contract to build a supercomputer that will drive France’s AI and HPC efforts. The computer will be part of GENCI, the Fre Read more…

By Tiffany Trader

  • arrow
  • Click Here for More Headlines
  • arrow
Do NOT follow this link or you will be banned from the site!
Share This