Barcelona Supercomputing Center Contributes to Pan-Cancer Project

February 7, 2020

Feb. 7, 2020 — An international team has completed the most comprehensive study of whole cancer genomes to date, significantly improving our fundamental understanding of cancer and signposting new directions for its diagnosis and treatment. The Barcelona Supercomputing Center (BSC) has been involved from the initial stages of this project, and has contributed with the analysis of data, with the design of specific computing solutions for cancer genomics, as well as in the answering of specific questions related to with the biology of tumors.

The ICGC/TCGA[1] Pan-Cancer Analysis of Whole Genomes Project (PCAWG), known as the Pan-Cancer Project, a collaboration involving more than 1,300 scientists and clinicians from 37 countries, analyzed more than 2,600 genomes of 38 different tumour types, creating a huge resource of primary cancer genomes. This was then the launch-point for 16 working groups studying multiple aspects of cancer’s development, causation, progression and classification.

Previous studies focused on the 1 per cent of the genome that codes for proteins, analogous to mapping the coasts of the continents. The Pan-Cancer Project explored in considerably greater detail the remaining 99 per cent of the genome, including key regions that control switching genes on and off — analogous to mapping the interiors of continents versus just their coastlines.

The Pan-Cancer Project has made available a comprehensive resource for cancer genomics research, including the raw genome sequencing data, software for cancer genome analysis, and multiple interactive websites exploring various aspects of the Pan-Cancer Project data.[2]

The role of High Perfomance Computing

Among the few data analysis centers around the world involved in the management and analysis of the PanCancer data, the BSC has been the most active European supercomputing center. Already involved in the early stages of this initiative, the BSC has had a wide contribution to the project, covering the primary analysis of genomes, including the detection of mutations; the generation of related computing resources; as well as the identification of non-functional gene copies that can have a direct impact on the offset and progression of tumors.

Two genome sequences from each donor (one from a healthy cell and one from a tumor cell) have been analyzed by different methods. With the BWA method, the two genomes of each donor were aligned with the reference human genome. Subsequently, the results of this alignment were analyzed with Sanger, DKFZ / EMBL, Broad / MUSE methods to compare the healthy and tumor genomes of the same patient and to detect possible mutations present in the tumor. In the BSC, 14% of these analyses were performed. One of the four methods of analysis (Broad / MUSE) has only been performed in the United States due to intellectual property issues in its algorithm.

“Beyond the specific discoveries regarding the biological processes behind the origin and progression of tumors, this effort has resulted in one of the largest international efforts in biomedicine, and has set up the path for future world-wide initiatives in relation to cancer genomics, and for Personalized Medicine in general” says Dr. David Torrents, ICREA research professor, leading the Computational Genomics groups at the BSC. “This project has placed our center among the top reference centers world-wide for data analysis in biomedicine and, in particular, for genomic oncology”.

New knowledge on cancer

The Pan-Cancer Project extended and advanced methods for analyzing cancer genomes which included cloud computing, and by applying these methods to its large dataset, discovered new knowledge about cancer biology and confirmed important findings of previous studies. In 23 papers published today in Nature and its affiliated journals, the Pan-Cancer Project reports that:

  • The cancer genome is finite and knowable, but enormously complicated. By combining sequencing of the whole cancer genome with a suite of analysis tools, we can characterize every genetic change found in a cancer, all the processes that have generated those mutations, and even the order of key events during a cancer’s life history.
  • Researchers are close to cataloguing all of the biological pathways involved in cancer and having a fuller picture of their actions in the genome. At least one causal mutation was found in virtually all of the cancers analyzed and the processes that generate mutations were found to be hugely diverse — from changes in single DNA letters to the reorganization of whole chromosomes. Multiple novel regions of the genome controlling how genes switch on and off were identified as targets of cancer-causing mutations.
  • Through a new method of “carbon dating,” Pan-Cancer researchers discovered that it is possible identify mutations which occurred years, sometimes even decades, before the tumour appears. This opens, theoretically, a window of opportunity for early cancer detection.
  • Tumour types can be identified accurately according to the patterns of genetic changes seen throughout the genome, potentially aiding the diagnosis of a patient’s cancer where conventional clinical tests could not identify its type. Knowledge of the exact tumour type could also help tailor treatments.

DOI: https://www.nature.com/articles/s41467-020-14367-0

1. ICGC – International Cancer Genome Consortium https://icgc.org/; TCGA – The Cancer Genome Atlas (https://www.cancer.gov/about-nci/organization/ccg/research/structural-genomics/tcga)

2. PCAWG Portal (dcc.icgc.org/pcawg); UCSC Xena (pcawg.xenahubs.net); Expression Atlas (www.ebi.ac.uk/gxa/home); PCAWG-Scout (pcawgscout.bsc.es); Chromothripsis Explorer (compbio.med.harvard.edu/chromothripsis)


Source: Barcelona Supercomputing Center

Subscribe to HPCwire's Weekly Update!

Be the most informed person in the room! Stay ahead of the tech trends with industy updates delivered to you every week!

AI Silicon Startup Graphcore Launches Channel Partner Program

September 23, 2020

AI compute platform vendor Graphcore has launched its first formal global channel partner program to promote and boost the sales of its AI processors and blade computing products. The formalized, all-new Graphcore Eli Read more…

By Todd R. Weiss

Arm Targets HPC with New Neoverse Platforms

September 22, 2020

UK-based semiconductor design company Arm today teased details of its Neoverse roadmap, introducing V1 (codenamed Zeus) and N2 (codenamed Perseus), Arm’s second generation N-series platform. The chip IP vendor said the Read more…

By Tiffany Trader

Microsoft’s Azure Quantum Platform Now Offers Toshiba’s ‘Simulated Bifurcation Machine’

September 22, 2020

While pure-play quantum computing (QC) gets most of the QC-related attention, there’s also been steady progress adapting quantum methods for select use on classical computers. Today, Microsoft announced that Toshiba’ Read more…

By John Russell

Oracle Cloud Deepens HPC Embrace with Launch of A100 Instances, Plans for Arm, More 

September 22, 2020

Oracle Cloud Infrastructure (OCI) continued its steady ramp-up of HPC capabilities today with a flurry of announcements. Topping the list is general availability of instances with Nvidia’s newest GPU, the A100. OCI als Read more…

By John Russell

IBM, CQC Enable Cloud-based Quantum Random Number Generation

September 21, 2020

IBM and Cambridge Quantum Computing (CQC) have partnered to achieve progress on one of the major business aspirations for quantum computing – the goal of generating verified, truly random numbers that can be used for a Read more…

By Todd R. Weiss

AWS Solution Channel

The Water Institute of the Gulf runs compute-heavy storm surge and wave simulations on AWS

The Water Institute of the Gulf (Water Institute) runs its storm surge and wave analysis models on Amazon Web Services (AWS)—a task that sometimes requires large bursts of compute power. Read more…

Intel® HPC + AI Pavilion

Berlin Institute of Health: Putting HPC to Work for the World

Researchers from the Center for Digital Health at the Berlin Institute of Health (BIH) are using science to understand the pathophysiology of COVID-19, which can help to inform the development of targeted treatments. Read more…

European Commission Declares €8 Billion Investment in Supercomputing

September 18, 2020

Just under two years ago, the European Commission formalized the EuroHPC Joint Undertaking (JU): a concerted HPC effort (comprising 32 participating states at current count) across the European Union and supplanting HPC Read more…

By Oliver Peckham

Arm Targets HPC with New Neoverse Platforms

September 22, 2020

UK-based semiconductor design company Arm today teased details of its Neoverse roadmap, introducing V1 (codenamed Zeus) and N2 (codenamed Perseus), Arm’s seco Read more…

By Tiffany Trader

Oracle Cloud Deepens HPC Embrace with Launch of A100 Instances, Plans for Arm, More 

September 22, 2020

Oracle Cloud Infrastructure (OCI) continued its steady ramp-up of HPC capabilities today with a flurry of announcements. Topping the list is general availabilit Read more…

By John Russell

European Commission Declares €8 Billion Investment in Supercomputing

September 18, 2020

Just under two years ago, the European Commission formalized the EuroHPC Joint Undertaking (JU): a concerted HPC effort (comprising 32 participating states at c Read more…

By Oliver Peckham

Google Hires Longtime Intel Exec Bill Magro to Lead HPC Strategy

September 18, 2020

In a sign of the times, another prominent HPCer has made a move to a hyperscaler. Longtime Intel executive Bill Magro joined Google as chief technologist for hi Read more…

By Tiffany Trader

Future of Fintech on Display at HPC + AI Wall Street

September 17, 2020

Those who tuned in for Tuesday's HPC + AI Wall Street event got a peak at the future of fintech and lively discussion of topics like blockchain, AI for risk man Read more…

By Alex Woodie, Tiffany Trader and Todd R. Weiss

IBM’s Quantum Race to One Million Qubits

September 15, 2020

IBM today outlined its ambitious quantum computing technology roadmap at its virtual Quantum Summit. The eye-popping million qubit number is still far out, agrees IBM, but perhaps not that far out. Just as eye-popping is IBM’s nearer-term plan for a 1,000-plus qubit system named Condor... Read more…

By John Russell

Nvidia Commits to Buy Arm for $40B

September 14, 2020

Nvidia is acquiring semiconductor design company Arm Ltd. for $40 billion from SoftBank in a blockbuster deal that catapults the GPU chipmaker to a dominant position in the datacenter while helping troubled SoftBank reverse its financial woes. The deal, which has been rumored for... Read more…

By Todd R. Weiss and George Leopold

AMD’s Massive COVID-19 HPC Fund Adds 18 Institutions, 5 Petaflops of Power

September 14, 2020

Almost exactly five months ago, AMD announced its COVID-19 HPC Fund, an ongoing flow of resources and equipment to research institutions studying COVID-19 that began with an initial donation of $15 million. In June, AMD announced major equipment donations to several major institutions. Now, AMD is making its third major COVID-19 HPC Fund... Read more…

By Oliver Peckham

Supercomputer-Powered Research Uncovers Signs of ‘Bradykinin Storm’ That May Explain COVID-19 Symptoms

July 28, 2020

Doctors and medical researchers have struggled to pinpoint – let alone explain – the deluge of symptoms induced by COVID-19 infections in patients, and what Read more…

By Oliver Peckham

Nvidia Said to Be Close on Arm Deal

August 3, 2020

GPU leader Nvidia Corp. is in talks to buy U.K. chip designer Arm from parent company Softbank, according to several reports over the weekend. If consummated Read more…

By George Leopold

10nm, 7nm, 5nm…. Should the Chip Nanometer Metric Be Replaced?

June 1, 2020

The biggest cool factor in server chips is the nanometer. AMD beating Intel to a CPU built on a 7nm process node* – with 5nm and 3nm on the way – has been i Read more…

By Doug Black

Intel’s 7nm Slip Raises Questions About Ponte Vecchio GPU, Aurora Supercomputer

July 30, 2020

During its second-quarter earnings call, Intel announced a one-year delay of its 7nm process technology, which it says it will create an approximate six-month shift for its CPU product timing relative to prior expectations. The primary issue is a defect mode in the 7nm process that resulted in yield degradation... Read more…

By Tiffany Trader

HPE Keeps Cray Brand Promise, Reveals HPE Cray Supercomputing Line

August 4, 2020

The HPC community, ever-affectionate toward Cray and its eponymous founder, can breathe a (virtual) sigh of relief. The Cray brand will live on, encompassing th Read more…

By Tiffany Trader

Google Hires Longtime Intel Exec Bill Magro to Lead HPC Strategy

September 18, 2020

In a sign of the times, another prominent HPCer has made a move to a hyperscaler. Longtime Intel executive Bill Magro joined Google as chief technologist for hi Read more…

By Tiffany Trader

Neocortex Will Be First-of-Its-Kind 800,000-Core AI Supercomputer

June 9, 2020

Pittsburgh Supercomputing Center (PSC - a joint research organization of Carnegie Mellon University and the University of Pittsburgh) has won a $5 million award Read more…

By Tiffany Trader

Supercomputer Modeling Tests How COVID-19 Spreads in Grocery Stores

April 8, 2020

In the COVID-19 era, many people are treating simple activities like getting gas or groceries with caution as they try to heed social distancing mandates and protect their own health. Still, significant uncertainty surrounds the relative risk of different activities, and conflicting information is prevalent. A team of Finnish researchers set out to address some of these uncertainties by... Read more…

By Oliver Peckham

Leading Solution Providers

Contributors

European Commission Declares €8 Billion Investment in Supercomputing

September 18, 2020

Just under two years ago, the European Commission formalized the EuroHPC Joint Undertaking (JU): a concerted HPC effort (comprising 32 participating states at c Read more…

By Oliver Peckham

Australian Researchers Break All-Time Internet Speed Record

May 26, 2020

If you’ve been stuck at home for the last few months, you’ve probably become more attuned to the quality (or lack thereof) of your internet connection. Even Read more…

By Oliver Peckham

Oracle Cloud Infrastructure Powers Fugaku’s Storage, Scores IO500 Win

August 28, 2020

In June, RIKEN shook the supercomputing world with its Arm-based, Fujitsu-built juggernaut: Fugaku. The system, which weighs in at 415.5 Linpack petaflops, topp Read more…

By Oliver Peckham

Google Cloud Debuts 16-GPU Ampere A100 Instances

July 7, 2020

On the heels of the Nvidia’s Ampere A100 GPU launch in May, Google Cloud is announcing alpha availability of the A100 “Accelerator Optimized” VM A2 instance family on Google Compute Engine. The instances are powered by the HGX A100 16-GPU platform, which combines two HGX A100 8-GPU baseboards using... Read more…

By Tiffany Trader

DOD Orders Two AI-Focused Supercomputers from Liqid

August 24, 2020

The U.S. Department of Defense is making a big investment in data analytics and AI computing with the procurement of two HPC systems that will provide the High Read more…

By Tiffany Trader

Microsoft Azure Adds A100 GPU Instances for ‘Supercomputer-Class AI’ in the Cloud

August 19, 2020

Microsoft Azure continues to infuse its cloud platform with HPC- and AI-directed technologies. Today the cloud services purveyor announced a new virtual machine Read more…

By Tiffany Trader

Japan’s Fugaku Tops Global Supercomputing Rankings

June 22, 2020

A new Top500 champ was unveiled today. Supercomputer Fugaku, the pride of Japan and the namesake of Mount Fuji, vaulted to the top of the 55th edition of the To Read more…

By Tiffany Trader

Joliot-Curie Supercomputer Used to Build First Full, High-Fidelity Aircraft Engine Simulation

July 14, 2020

When industrial designers plan the design of a new element of a vehicle’s propulsion or exterior, they typically use fluid dynamics to optimize airflow and in Read more…

By Oliver Peckham

  • arrow
  • Click Here for More Headlines
  • arrow
Do NOT follow this link or you will be banned from the site!
Share This