Imec Introduces CMOS Chip With 16,384 Micro-Electrodes and 1,024 Channels for Multimodal Cell Interfacing

February 12, 2018

LEUVEN, Belgium, Feb. 12, 2018 — Imec, a world-leading research and innovation hub in nanoelectronics and digital technologies, has designed and fabricated a 16,384-electrode, 1,024-channel micro-electrode array (MEA) for high-throughput multi-modal cell interfacing. The chip offers intracellular and extracellular recording, voltage- and current-controlled stimulation, impedance monitoring and spectroscopy functionalities thereby packing the most cell-interfacing modalities on a single chip, and being the only one to enable multi-well assays. With this new chip, imec has created a platform that enables high quality data acquisition at increased throughput in cell-based cell studies. Imec’s micro-electrode array chip will be presented at ISSCC in San Francisco, Feb. 11-15.

MEAs have since long been used for in vitro cell-interaction experiments. However, most of today’s MEAs do not support high throughput measurements, making current cell-assays time-consuming. They are typically passive devices, without built-in circuitry, therefore requiring complex external equipment for data acquisition. Additionally, most MEAs are not able to accommodate the extra sensing modalities to fully characterize complex cell behavior and interactions.

Imec’s high-throughput multi-modal CMOS-MEA packs 16,384 active electrodes with signal processing, filtering and analog-to-digital conversion on-chip, resulting in a very complete and compact system with easy interfacing. To improve the signal quality, each electrode has a miniature pre-amplifier. The electrodes are grouped in 16 clusters, each of which can be addressed individually, making it possible to run 16 experiments independently and simultaneously. This CMOS-MEA also includes 1,024 low-noise readout channels that can be connected to any of the 16,384 electrodes. The custom reconfigurable on-chip circuits support 6 cell-interfacing modalities: both extra- and intracellular electrical activity recording, constant voltage and constant current stimulation for cell excitation or localized electroporation, fast impedance monitoring and, finally, impedance spectroscopy. While fast impedance monitoring can detect impedance changes over time and cell presence for optimal electrode selection, single-cell impedance spectroscopy gives detailed information of the electrode impedance, seal resistance and cell-membrane impedance which can be used for cell differentiation. Imec’s high input impedance, low noise and low power reconfigurable circuits make it possible to integrate 1,024 parallel readout channels and 64 reconfigurable stimulation units on a small chip area.

“Not only are we reporting the highest number of modalities so far on a single chip with a very high channel count, we are able to achieve this without any performance penalty. Moreover, by offering six modalities on such large scale, the imec CMOS-MEA will greatly improve the throughput and versatility of cell-based assays,” commented Nick Van Helleputte, manager biomedical circuits at imec. “With the introduction of CMOS chip technology into the MEA-technology, we have realized a breakthrough in cell interfacing.”

These results will be presented at ISSCC2018 on Feb 14, 2018 in session 29: Advanced Biomedical Systems at 2.30 pm: 29.3 – A 16384-Electrode 1024-Channel Multimodal CMOS MEA for High-Throughput Intracellular Action Potential Measurements and Impedance Spectroscopy in Drug-Screening Applications, C. Mora Lopez et al. (imec).

About imec

Imec is a world-leading research and innovation hub in nanoelectronics and digital technologies. The combination of our widely acclaimed leadership in microchip technology and profound software and ICT expertise is what makes us unique. By leveraging our world-class infrastructure and local and global ecosystem of partners across a multitude of industries, we create groundbreaking innovation in application domains such as healthcare, smart cities and mobility, logistics and manufacturing, energy and education.


Source: imec

Subscribe to HPCwire's Weekly Update!

Be the most informed person in the room! Stay ahead of the tech trends with industy updates delivered to you every week!

Nvidia Debuts Turing Architecture, Focusing on Real-Time Ray Tracing

August 16, 2018

From the SIGGRAPH professional graphics conference in Vancouver this week, Nvidia CEO Jensen Huang unveiled Turing, the company's next-gen GPU platform that introduces new RT Cores to accelerate ray tracing and new Tenso Read more…

By Tiffany Trader

HPC Coding: The Power of L(o)osing Control

August 16, 2018

Exascale roadmaps, exascale projects and exascale lobbyists ask, on-again-off-again, for a fundamental rewrite of major code building blocks. Otherwise, so they claim, codes will not scale up. Naturally, some exascale pr Read more…

By Tobias Weinzierl

STAQ(ing) the Quantum Computing Deck

August 16, 2018

Quantum computers – at least for now – remain noisy. That’s another way of saying unreliable and in diverse ways that often depend on the specific quantum technology used. One idea is to mitigate noisiness and perh Read more…

By John Russell

HPE Extreme Performance Solutions

Introducing the First Integrated System Management Software for HPC Clusters from HPE

How do you manage your complex, growing cluster environments? Answer that big challenge with the new HPC cluster management solution: HPE Performance Cluster Manager. Read more…

IBM Accelerated Insights

Super Problem Solving

You might think that tackling the world’s toughest problems is a job only for superheroes, but at special places such as the Oak Ridge National Laboratory, supercomputers are the real heroes. Read more…

NREL ‘Eagle’ Supercomputer to Advance Energy Tech R&D

August 14, 2018

The U.S. Department of Energy (DOE) National Renewable Energy Laboratory (NREL) has contracted with Hewlett Packard Enterprise (HPE) for a new 8-petaflops (peak) supercomputer that will be used to advance early-stage R&a Read more…

By Tiffany Trader

STAQ(ing) the Quantum Computing Deck

August 16, 2018

Quantum computers – at least for now – remain noisy. That’s another way of saying unreliable and in diverse ways that often depend on the specific quantum Read more…

By John Russell

NREL ‘Eagle’ Supercomputer to Advance Energy Tech R&D

August 14, 2018

The U.S. Department of Energy (DOE) National Renewable Energy Laboratory (NREL) has contracted with Hewlett Packard Enterprise (HPE) for a new 8-petaflops (peak Read more…

By Tiffany Trader

CERN Project Sees Orders-of-Magnitude Speedup with AI Approach

August 14, 2018

An award-winning effort at CERN has demonstrated potential to significantly change how the physics based modeling and simulation communities view machine learni Read more…

By Rob Farber

Intel Announces Cooper Lake, Advances AI Strategy

August 9, 2018

Intel's chief datacenter exec Navin Shenoy kicked off the company's Data-Centric Innovation Summit Wednesday, the day-long program devoted to Intel's datacenter Read more…

By Tiffany Trader

SLATE Update: Making Math Libraries Exascale-ready

August 9, 2018

Practically-speaking, achieving exascale computing requires enabling HPC software to effectively use accelerators – mostly GPUs at present – and that remain Read more…

By John Russell

Summertime in Washington: Some Unexpected Advanced Computing News

August 8, 2018

Summertime in Washington DC is known for its heat and humidity. That is why most people get away to either the mountains or the seashore and things slow down. H Read more…

By Alex R. Larzelere

NSF Invests $15 Million in Quantum STAQ

August 7, 2018

Quantum computing development is in full ascent as global backers aim to transcend the limitations of classical computing by leveraging the magical-seeming prop Read more…

By Tiffany Trader

By the Numbers: Cray Would Like Exascale to Be the Icing on the Cake

August 1, 2018

On its earnings call held for investors yesterday, Cray gave an accounting for its latest quarterly financials, offered future guidance and provided an update o Read more…

By Tiffany Trader

Leading Solution Providers

SC17 Booth Video Tours Playlist

Altair @ SC17

Altair

AMD @ SC17

AMD

ASRock Rack @ SC17

ASRock Rack

CEJN @ SC17

CEJN

DDN Storage @ SC17

DDN Storage

Huawei @ SC17

Huawei

IBM @ SC17

IBM

IBM Power Systems @ SC17

IBM Power Systems

Intel @ SC17

Intel

Lenovo @ SC17

Lenovo

Mellanox Technologies @ SC17

Mellanox Technologies

Microsoft @ SC17

Microsoft

Penguin Computing @ SC17

Penguin Computing

Pure Storage @ SC17

Pure Storage

Supericro @ SC17

Supericro

Tyan @ SC17

Tyan

Univa @ SC17

Univa

  • arrow
  • Click Here for More Headlines
  • arrow
Do NOT follow this link or you will be banned from the site!
Share This