Pumas-AI Launches Pumas Software to Advance Drug Development, Patient Care

July 23, 2019

BALTIMORE, July 23, 2019 — Pumas-AI, a new company established by University of Maryland School of Pharmacy faculty members Vijay Ivaturi, PhD, assistant professor in the Department of Pharmacy Practice and Science (PPS), and Joga Gobburu, PhD, MBA, professor in PPS – is proud to announce the release of its first cutting-edge software platform for pharmaceutical researchers and clinicians. Known as Pharmaceutical Modeling and Simulation (Pumas), the software was developed through a partnership with experts at Julia Computing. Research and software development efforts were led by Christopher Rackauckas, PhD, senior research analyst in PPS, with input from independent contributor Joakim Nyberg, PhD, from Uppsala, Sweden.

“The success rate for pharmaceutical innovations is approximately two percent,” says Gobburu, who also serves as executive director of the Center for Translational Medicine (CTM) at the School of Pharmacy. “Pumas software is tailored to revolutionize big data analytics in health care, unlike those tools used in other fields. By combining the extensive health care knowledge of our faculty and staff with the scientific computing experts at Julia Computing, we have developed a tool that will not only benefit business leaders working in the pharmaceutical industry, but also those who are caring for patients on the frontline of health care delivery.”

Pumas is the first software platform released by Pumas-AI, whose goal is to double pharmaceutical and patient care success rates by democratizing tools and education in the health care data analytics space. The Pumas software platform provides a wide range of analytic capabilities for pharmaceutical and biotechnology development, as well as therapeutic decision making – addressing a crucial need for pharmaceutical companies and investors, who often base their decisions on a combination of technical, regulatory, and commercial success probabilities, all of which the Pumas software can provide quantitatively.

“Pumas is our company’s first product specifically designed for professionals in the pharmaceutical and health delivery sectors to bridge this gap,” adds Gobburu. “It leverages the Julia programming language, and combines modern artificial intelligence (AI) with traditional mechanistic models, allowing the CTM to foster one of its goals of enhancing real-world data (RWD) analytics through its newly formed Health Analytics Collective (HAC).”

A comprehensive platform based on the Julia programming language, Pumas contains multiple modules designed to meet the needs of analysts in the pharmaceutical industry, while also working to advance therapeutic innovation in the clinic setting. Julia was selected for its speed and succinctness as a programming language, which produces an interface that looks similar to R, but operates at the speed of FORTRAN. Because Pumas is created entirely in Julia, users can make direct use of the language’s database, statistics, and visualization functionality – all without losing performance.

In addition, Julia is the programming language of choice for prominent researchers at institutions such as the Massachusetts Institute of Technology (MIT) who work on projects at the cutting-edge of machine learning, as well as in differential equations research, which means that, unlike many other tools, Pumas has the unique ability to directly incorporate modern techniques to achieve maximal efficiency and accuracy.

“Pumas is the first pharmaceutical modeling suite that is designed from the ground up to use modern graphics processing unit (GPU) hardware, parallelized stiff differential equation solvers, and allow for the integration of machine learning with pharmacometrics,” says Rackauckas. “We are excited to not only accelerate current workflows, but also help users explore the new, realistic models that are enabled by this technology.”

Pumas will be the topic of a workshop at JuliaCon 2019, the year’s biggest Julia conference for developers, enthusiasts, and others. JuliaCon will be held at the University of Maryland, Baltimore in Baltimore, Md., from July 23 to 26, 2019, including a full day of preconference workshops scheduled for July 22.

A preconference workshop hosted by the CTM that day will highlight the Pumas software platform.

“At the CTM, we strive to develop point-of-care solutions for providers and clinicians that can help individualize treatment for patients,” says Ivaturi, who also serves as a pharmacometrician in the CTM at the School. “The Pumas software platform will be instrumental in helping us optimize treatments for a number of conditions and therapeutics.”

He adds, “It is going to revolutionize therapeutic decision making and allow health care organizations to benefit from payor incentives by demonstrating substantial improvements to successful patient care.”

Researchers and clinicians can learn more about Pumas at www.pumas.ai.

About Pumas-AI

Pumas-AI was established by University of Maryland School of Pharmacy faculty members: Vijay Ivaturi, PhD, assistant professor in PPS, and Joga Gobburu, PhD, MBA, professor in PPS and executive director of the Center for Translational Medicine at the School. Pumas-AI’s vision is to double pharmaceutical and patient care success by democratizing tools and education in the health care data analytics space. Pumas is its first product developed to provide analytic capabilities for drug/biotech development and therapeutic decision making.  It leverages the power of the Julia programming language to combine modern AI with traditional mechanistic models to gain massive computational efficiency.

About Center for Translational Medicine

Established in 2011, the Center for Translational Medicine (CTM) analyzes and summarizes data from experiments and clinical trials using quantitative disease, drug, and trial models, with the goal of reducing the time it takes to bring a drug to market. Its quantitative models, along with state-of-the-art development techniques – such as adaptive and enrichment trials – are integrated into tools that drug developers, regulatory agencies, and other research organizations can use to guide decisions pertaining to “go/no-go”, dosage, patient population, design, endpoint, analyses, and therapeutics choices.

About the University of Maryland School of Pharmacy

Established in 1841, the University of Maryland School of Pharmacy is ranked as one of the top 10 schools of pharmacy in the United States. It is a thriving center for professional and graduate education, pharmaceutical care, research, and community service. It creates the future of pharmacy by pioneering new roles for pharmacists in advanced clinical practice and conducting cutting-edge research in drug discovery and development, comparative effectiveness and patient-centered outcomes, and disease management. Faculty inspire excellence in more than 800 students, residents, and postdoctoral fellows through a contemporary curriculum, innovative educational experiences, and strategic professional relationships.

About Julia Computing

Julia Computing was founded by the creators of Julia. Julia is an open-source language for high-performance scientific computing, data science, and AI developed by a community that consists of some of the best people in these fields. It solves the long standing two-language problem by combining the simplicity and ease of use of dynamic languages such as Python and R with the performance of statically typed languages such as C++ – for which its creators were awarded the 2019 James H. Wilkinson Prize for Numerical Software. Julia is now taught and used for research at hundreds of universities worldwide, including MIT, Stanford, UC Berkeley and Cornell to name a few. Julia Computing’s mission is to develop products that make Julia easy to use, easy to deploy and easy to scale. It does so through a suite of products – JuliaSure, JuliaTeam and JuliaPro, which are used by hundreds of enterprises and universities worldwide. For new users of Julia, live and online trainings are offered through JuliaAcademy.

About Health Analytics Collective

The Health Analytics Collective is a group founded by the CTM, MIT, Julia Computing, and MMS Holdings that plans to use Pumas as part of an end-to-end solution for data science and real world evidence analytics, allowing for the ingestion, transformation, and analysis of all data in one system. The group aims to leverage real-world evidence, observational data that are generated during routine clinical practice, and patient health care databases to augment label claims and/or support new drug applications with leading-edge software and algorithms and a depth of regulatory and clinical experience.


Source: Julia Computing 

Subscribe to HPCwire's Weekly Update!

Be the most informed person in the room! Stay ahead of the tech trends with industy updates delivered to you every week!

NIST/Xanadu Researchers Report Photonic Quantum Computing Advance

March 3, 2021

Researchers from the National Institute of Standards and Technology (NIST) and Xanadu, a young Canada-based quantum computing company, have reported developing a full-stack, photonic quantum computer able to carry out th Read more…

By John Russell

Can Deep Learning Replace Numerical Weather Prediction?

March 3, 2021

Numerical weather prediction (NWP) is a mainstay of supercomputing. Some of the first applications of the first supercomputers dealt with climate modeling, and even to this day, the largest climate models are heavily con Read more…

By Oliver Peckham

HPE Names Justin Hotard New HPC Chief as Pete Ungaro Departs

March 2, 2021

HPE CEO Antonio Neri announced today (March 2, 2020) the appointment of Justin Hotard as general manager of HPC, mission critical solutions and labs, effective immediately. Hotard replaces long-time Cray exec Pete Ungaro Read more…

By Tiffany Trader

ORNL’s Jeffrey Vetter on How IRIS Runtime will Help Deal with Extreme Heterogeneity

March 2, 2021

Jeffery Vetter is a familiar figure in HPC. Last year he became one of the new section heads in a reorganization at Oak Ridge National Laboratory. He had been founding director of ORNL's Future Technologies Group which i Read more…

By John Russell

HPC Career Notes: March 2021 Edition

March 1, 2021

In this monthly feature, we’ll keep you up-to-date on the latest career developments for individuals in the high-performance computing community. Whether it’s a promotion, new company hire, or even an accolade, we’ Read more…

By Mariana Iriarte

AWS Solution Channel

Moderna Accelerates COVID-19 Vaccine Development on AWS

Marcello Damiani, Chief Digital and Operational Excellence Officer at Moderna, joins Todd Weatherby, Vice President of AWS Professional Services Worldwide, for a discussion on developing Moderna’s COVID-19 vaccine, scaling systems to enable global distribution, and leveraging cloud technologies to accelerate processes. Read more…

Supercomputers Enable First Holistic Model of SARS-CoV-2, Showing Spike Proteins Move in Tandem

February 28, 2021

Most models of SARS-CoV-2, the coronavirus that causes COVID-19, hone in on key features of the virus: for instance, the spike protein. Some of this is attributable to the relative importance of those features, but most Read more…

By Oliver Peckham

Can Deep Learning Replace Numerical Weather Prediction?

March 3, 2021

Numerical weather prediction (NWP) is a mainstay of supercomputing. Some of the first applications of the first supercomputers dealt with climate modeling, and Read more…

By Oliver Peckham

HPE Names Justin Hotard New HPC Chief as Pete Ungaro Departs

March 2, 2021

HPE CEO Antonio Neri announced today (March 2, 2020) the appointment of Justin Hotard as general manager of HPC, mission critical solutions and labs, effective Read more…

By Tiffany Trader

ORNL’s Jeffrey Vetter on How IRIS Runtime will Help Deal with Extreme Heterogeneity

March 2, 2021

Jeffery Vetter is a familiar figure in HPC. Last year he became one of the new section heads in a reorganization at Oak Ridge National Laboratory. He had been f Read more…

By John Russell

HPC Career Notes: March 2021 Edition

March 1, 2021

In this monthly feature, we’ll keep you up-to-date on the latest career developments for individuals in the high-performance computing community. Whether it Read more…

By Mariana Iriarte

African Supercomputing Center Inaugurates ‘Toubkal,’ Most Powerful Supercomputer on the Continent

February 25, 2021

Historically, Africa hasn’t exactly been synonymous with supercomputing. There are only a handful of supercomputers on the continent, with few ranking on the Read more…

By Oliver Peckham

Japan to Debut Integrated Fujitsu HPC/AI Supercomputer This Spring

February 25, 2021

The integrated Fujitsu HPC/AI Supercomputer, Wisteria, is coming to Japan this spring. The University of Tokyo is preparing to deploy a heterogeneous computing Read more…

By Tiffany Trader

Xilinx Launches Alveo SN1000 SmartNIC

February 24, 2021

FPGA vendor Xilinx has debuted its latest SmartNIC model, the Alveo SN1000, with integrated “composability” features that allow enterprise users to add their own custom networking functions to supplement its built-in networking. By providing deep flexibility... Read more…

By Todd R. Weiss

ASF Keynotes Showcase How HPC and Big Data Have Pervaded the Pandemic

February 24, 2021

Last Thursday, a range of experts joined the Advanced Scale Forum (ASF) in a rapid-fire roundtable to discuss how advanced technologies have transformed the way humanity responded to the COVID-19 pandemic in indelible ways. The roundtable, held near the one-year mark of the first... Read more…

By Oliver Peckham

Julia Update: Adoption Keeps Climbing; Is It a Python Challenger?

January 13, 2021

The rapid adoption of Julia, the open source, high level programing language with roots at MIT, shows no sign of slowing according to data from Julialang.org. I Read more…

By John Russell

Esperanto Unveils ML Chip with Nearly 1,100 RISC-V Cores

December 8, 2020

At the RISC-V Summit today, Art Swift, CEO of Esperanto Technologies, announced a new, RISC-V based chip aimed at machine learning and containing nearly 1,100 low-power cores based on the open-source RISC-V architecture. Esperanto Technologies, headquartered in... Read more…

By Oliver Peckham

Azure Scaled to Record 86,400 Cores for Molecular Dynamics

November 20, 2020

A new record for HPC scaling on the public cloud has been achieved on Microsoft Azure. Led by Dr. Jer-Ming Chia, the cloud provider partnered with the Beckman I Read more…

By Oliver Peckham

Programming the Soon-to-Be World’s Fastest Supercomputer, Frontier

January 5, 2021

What’s it like designing an app for the world’s fastest supercomputer, set to come online in the United States in 2021? The University of Delaware’s Sunita Chandrasekaran is leading an elite international team in just that task. Chandrasekaran, assistant professor of computer and information sciences, recently was named... Read more…

By Tracey Bryant

NICS Unleashes ‘Kraken’ Supercomputer

April 4, 2008

A Cray XT4 supercomputer, dubbed Kraken, is scheduled to come online in mid-summer at the National Institute for Computational Sciences (NICS). The soon-to-be petascale system, and the resulting NICS organization, are the result of an NSF Track II award of $65 million to the University of Tennessee and its partners to provide next-generation supercomputing for the nation's science community. Read more…

10nm, 7nm, 5nm…. Should the Chip Nanometer Metric Be Replaced?

June 1, 2020

The biggest cool factor in server chips is the nanometer. AMD beating Intel to a CPU built on a 7nm process node* – with 5nm and 3nm on the way – has been i Read more…

By Doug Black

Top500: Fugaku Keeps Crown, Nvidia’s Selene Climbs to #5

November 16, 2020

With the publication of the 56th Top500 list today from SC20's virtual proceedings, Japan's Fugaku supercomputer – now fully deployed – notches another win, Read more…

By Tiffany Trader

Gordon Bell Special Prize Goes to Massive SARS-CoV-2 Simulations

November 19, 2020

2020 has proven a harrowing year – but it has produced remarkable heroes. To that end, this year, the Association for Computing Machinery (ACM) introduced the Read more…

By Oliver Peckham

Leading Solution Providers

Contributors

Texas A&M Announces Flagship ‘Grace’ Supercomputer

November 9, 2020

Texas A&M University has announced its next flagship system: Grace. The new supercomputer, named for legendary programming pioneer Grace Hopper, is replacing the Ada system (itself named for mathematician Ada Lovelace) as the primary workhorse for Texas A&M’s High Performance Research Computing (HPRC). Read more…

By Oliver Peckham

Saudi Aramco Unveils Dammam 7, Its New Top Ten Supercomputer

January 21, 2021

By revenue, oil and gas giant Saudi Aramco is one of the largest companies in the world, and it has historically employed commensurate amounts of supercomputing Read more…

By Oliver Peckham

Intel Xe-HP GPU Deployed for Aurora Exascale Development

November 17, 2020

At SC20, Intel announced that it is making its Xe-HP high performance discrete GPUs available to early access developers. Notably, the new chips have been deplo Read more…

By Tiffany Trader

Intel Teases Ice Lake-SP, Shows Competitive Benchmarking

November 17, 2020

At SC20 this week, Intel teased its forthcoming third-generation Xeon "Ice Lake-SP" server processor, claiming competitive benchmarking results against AMD's second-generation Epyc "Rome" processor. Ice Lake-SP, Intel's first server processor with 10nm technology... Read more…

By Tiffany Trader

New Deep Learning Algorithm Solves Rubik’s Cube

July 25, 2018

Solving (and attempting to solve) Rubik’s Cube has delighted millions of puzzle lovers since 1974 when the cube was invented by Hungarian sculptor and archite Read more…

By John Russell

Livermore’s El Capitan Supercomputer to Debut HPE ‘Rabbit’ Near Node Local Storage

February 18, 2021

A near node local storage innovation called Rabbit factored heavily into Lawrence Livermore National Laboratory’s decision to select Cray’s proposal for its CORAL-2 machine, the lab’s first exascale-class supercomputer, El Capitan. Details of this new storage technology were revealed... Read more…

By Tiffany Trader

It’s Fugaku vs. COVID-19: How the World’s Top Supercomputer Is Shaping Our New Normal

November 9, 2020

Fugaku is currently the most powerful publicly ranked supercomputer in the world – but we weren’t supposed to have it yet. The supercomputer, situated at Japan’s Riken scientific research institute, was scheduled to come online in 2021. When the pandemic struck... Read more…

By Oliver Peckham

African Supercomputing Center Inaugurates ‘Toubkal,’ Most Powerful Supercomputer on the Continent

February 25, 2021

Historically, Africa hasn’t exactly been synonymous with supercomputing. There are only a handful of supercomputers on the continent, with few ranking on the Read more…

By Oliver Peckham

  • arrow
  • Click Here for More Headlines
  • arrow
HPCwire