Research on Blue Waters Points to Cheaper DNA Sequencing with Graphene

February 19, 2018

Feb. 19 — Since its discovery in 2004, graphene has captured imaginations and sparked innovation in the scientific community. Perhaps rightly so as it is 200 times stronger than the strongest steel but still flexible, incredibly light but extremely tough, and conducts heat and electricity more efficiently than copper. Professor Jerry Bernholc of North Carolina State University is utilizing the National Center for Supercomputing Applications’ Blue Waters supercomputer at the University of Illinois at Urbana-Champaign to explore graphene’s applications, including its use in nanoscale electronics and electrical DNA sequencing.

Graphene and Nanoscale Electronics

Currently, the trend toward smaller silicon semiconductors seems to be slowing down as it reaches limits of small scale. The world is moving past Moore’s Law, the idea that every two years computer processing speed will double and costs will decrease. Transistor density is still increasing but speed increases have slowed dramatically. In addition to that, systems are no longer shrinking like they did in the past as transistors reach physical limits.

This is bad news for those trying to use very fast computers, or any electronics for that matter, that have been getting thinner and thinner.

However, graphene may be a new way forward.

“We’re looking at what’s beyond Moore’s law, whether one can devise very small transistors based on only one atomic layer, using new methods of making materials,” Bernholc says. “We are looking at potential transistor structures consisting of a single layer of graphene, etched into lines of nanoribbons, where the carbon atoms are arranged like a chicken wire pattern. We are looking at which structures will function well, at a few atoms of width.”

Trying to do computations like this on normal computers is impossible, so Bernholc and his team utilized the Blue Waters supercomputer.

“We are doing quantum mechanical computations with thousands of atoms, and several thousands of electrons, and that requires very fast, very powerful systems, and we need to do calculations in parallel,” Bernholc says. “The computer chips are not fast enough—one computer chip in a desktop machine cannot do such calculations. On Blue Waters, we use thousands of nodes in parallel, so we can complete quantum mechanical calculations in a time that’s practical and receive results in a timely fashion.”

GRAPHENE AND DNA SEQUENCING

Bernholc is among the researchers who think that graphene may also play a major role in the push to decrease prices for gene sequencing. With 19 companies offering personal, direct-to-consumer genetics tests, it is easier than ever to sequence DNA, learning your family history and identifying genetic risks.

Some forms of sequencing DNA include electrophoresis, which involves running a current through gel with DNA segments in it, causing DNA strands of varying lengths to move to different locations (shorter strands move faster). This allows comparison between known DNA strands and unknown ones.

As graphene is an excellent conductor of electricity, it is not surprising its use in gene sequencing is being explored. Recently, a group of researchers in California explored the possibility of using nanotubes (a tubular cousin of graphene) to electrically detect a single nucleotide addition during DNA replication. If the nucleotides can also be distinguished electrically, one would be able to sequence DNA and other genetic materials more cheaply and accurately. Currently, DNA sequencing involves complex labeling and readout schemes, which are quite costly and time-consuming. But nanotubes could lead to a simple nanocircuit that could operate faster and be much cheaper.

Bernholc and his team ran calculations to reproduce the California experiment, but changed the electrical conditions. This enabled them to perform calculations that allowed for some DNA base pairs to be distinguished, but not others. There are four chemical bases that are used to store information in DNA: adenine (A), guanine (G), cytosine (C) and thymine (T). The sequence of the DNA tells the cells in your body what proteins and chemicals to make. The bases pair up with each other (A with T and C with G) to form base pairs.

“That allows us to distinguish A from T. G and T are very clear, we can tell G and T from C and A, but we cannot distinguish C and A at the moment using graphene,” Bernholc says. “That’s where more work is needed, but we are moving towards being able to have a new way to sequence DNA.”

For Bernholc’s team and other researchers, the possibilities for graphene’s applications—nanoscale electronics, DNA sequencing and beyond—seem endless.

About NCSA

The National Center for Supercomputing Applications (NCSA) at the University of Illinois at Urbana-Champaign provides supercomputing and advanced digital resources for the nation’s science enterprise. At NCSA, University of Illinois faculty, staff, students, and collaborators from around the globe use advanced digital resources to address research grand challenges for the benefit of science and society. NCSA has been advancing one third of the Fortune 50® for more than 30 years by bringing industry, researchers, and students together to solve grand challenges at rapid speed and scale.

About the Blue Waters Project

The Blue Waters petascale supercomputer is one of the most powerful supercomputers in the world, and is the fastest sustained supercomputer on a university campus. Blue Waters uses hundreds of thousands of computational cores to achieve peak performance of more than 13 quadrillion calculations per second. Blue Waters has more memory and faster data storage than any other open system in the world. Scientists and engineers across the country use the computing and data power of Blue Waters to tackle a wide range of challenges. Recent advances that were not possible without these resources include computationally designing the first set of antibody prototypes to detect the Ebola virus, simulating the HIV capsid, visualizing the formation of the first galaxies and exploding stars, and understanding how the layout of a city can impact supercell thunderstorms.


Source: Susan Szuch, NCSA

Subscribe to HPCwire's Weekly Update!

Be the most informed person in the room! Stay ahead of the tech trends with industy updates delivered to you every week!

HPC Career Notes: August 2021 Edition

August 4, 2021

In this monthly feature, we’ll keep you up-to-date on the latest career developments for individuals in the high-performance computing community. Whether it’s a promotion, new company hire, or even an accolade, we’ Read more…

The Promise (and Necessity) of Runtime Systems like Charm++ in Exascale Power Management

August 4, 2021

Big heterogeneous computer systems, especially forthcoming exascale computers, are power hungry and difficult to program effectively. This is, of course, not an unrecognized problem. In a recent blog, Charmworks’ CEO S Read more…

Digging into the Atos-Nimbix Deal: Big US HPC and Global Cloud Aspirations. Look out HPE?

August 2, 2021

Behind Atos’s deal announced last week to acquire HPC-cloud specialist Nimbix are ramped-up plans to penetrate the U.S. HPC market and global expansion of its HPC cloud capabilities. Nimbix will become “an Atos HPC c Read more…

Berkeley Lab Makes Strides in Autonomous Discovery to Tackle the Data Deluge

August 2, 2021

Data production is outpacing the human capacity to process said data. Whether a giant radio telescope, a new particle accelerator or lidar data from autonomous cars, the sheer scale of the data generated is increasingly Read more…

Verifying the Universe with Exascale Computers

July 30, 2021

The ExaSky project, one of the critical Earth and Space Science applications being solved by the US Department of Energy’s (DOE’s) Exascale Computing Project (ECP), is preparing to use the nation’s forthcoming exas Read more…

AWS Solution Channel

Pushing pixels, not data with NICE DCV

NICE DCV, our high-performance, low-latency remote-display protocol, was originally created for scientists and engineers who ran large workloads on far-away supercomputers, but needed to visualize data without moving it. Read more…

What’s After Exascale? The Internet of Workflows Says HPE’s Nicolas Dubé

July 29, 2021

With the race to exascale computing in its final leg, it’s natural to wonder what the Post Exascale Era will look like. Nicolas Dubé, VP and chief technologist for HPE’s HPC business unit, agrees and shared his vision at Supercomputing Frontiers Europe 2021 held last week. The next big thing, he told the virtual audience at SFE21, is something that will connect HPC and (broadly) all of IT – into what Dubé calls The Internet of Workflows. Read more…

Digging into the Atos-Nimbix Deal: Big US HPC and Global Cloud Aspirations. Look out HPE?

August 2, 2021

Behind Atos’s deal announced last week to acquire HPC-cloud specialist Nimbix are ramped-up plans to penetrate the U.S. HPC market and global expansion of its Read more…

What’s After Exascale? The Internet of Workflows Says HPE’s Nicolas Dubé

July 29, 2021

With the race to exascale computing in its final leg, it’s natural to wonder what the Post Exascale Era will look like. Nicolas Dubé, VP and chief technologist for HPE’s HPC business unit, agrees and shared his vision at Supercomputing Frontiers Europe 2021 held last week. The next big thing, he told the virtual audience at SFE21, is something that will connect HPC and (broadly) all of IT – into what Dubé calls The Internet of Workflows. Read more…

How UK Scientists Developed Transformative, HPC-Powered Coronavirus Sequencing System

July 29, 2021

In November 2020, the COVID-19 Genomics UK Consortium (COG-UK) won the HPCwire Readers’ Choice Award for Best HPC Collaboration for its CLIMB-COVID sequencing project. Launched in March 2020, CLIMB-COVID has now resulted in the sequencing of over 675,000 coronavirus genomes – an increasingly critical task as variants like Delta threaten the tenuous prospect of a return to normalcy in much of the world. Read more…

IBM and University of Tokyo Roll Out Quantum System One in Japan

July 27, 2021

IBM and the University of Tokyo today unveiled an IBM Quantum System One as part of the IBM-Japan quantum program announced in 2019. The system is the second IB Read more…

Intel Unveils New Node Names; Sapphire Rapids Is Now an ‘Intel 7’ CPU

July 27, 2021

What's a preeminent chip company to do when its process node technology lags the competition by (roughly) one generation, but outmoded naming conventions make it seem like it's two nodes behind? For Intel, the response was to change how it refers to its nodes with the aim of better reflecting its positioning within the leadership semiconductor manufacturing space. Intel revealed its new node nomenclature, and... Read more…

Will Approximation Drive Post-Moore’s Law HPC Gains?

July 26, 2021

“Hardware-based improvements are going to get more and more difficult,” said Neil Thompson, an innovation scholar at MIT’s Computer Science and Artificial Intelligence Lab (CSAIL). “I think that’s something that this crowd will probably, actually, be already familiar with.” Thompson, speaking... Read more…

With New Owner and New Roadmap, an Independent Omni-Path Is Staging a Comeback

July 23, 2021

Put on a shelf by Intel in 2019, Omni-Path faced a uncertain future, but under new custodian Cornelis Networks, OmniPath is looking to make a comeback as an independent high-performance interconnect solution. A "significant refresh" – called Omni-Path Express – is coming later this year according to the company. Cornelis Networks formed last September as a spinout of Intel's Omni-Path division. Read more…

Chameleon’s HPC Testbed Sharpens Its Edge, Presses ‘Replay’

July 22, 2021

“One way of saying what I do for a living is to say that I develop scientific instruments,” said Kate Keahey, a senior fellow at the University of Chicago a Read more…

AMD Chipmaker TSMC to Use AMD Chips for Chipmaking

May 8, 2021

TSMC has tapped AMD to support its major manufacturing and R&D workloads. AMD will provide its Epyc Rome 7702P CPUs – with 64 cores operating at a base cl Read more…

Berkeley Lab Debuts Perlmutter, World’s Fastest AI Supercomputer

May 27, 2021

A ribbon-cutting ceremony held virtually at Berkeley Lab's National Energy Research Scientific Computing Center (NERSC) today marked the official launch of Perlmutter – aka NERSC-9 – the GPU-accelerated supercomputer built by HPE in partnership with Nvidia and AMD. Read more…

Ahead of ‘Dojo,’ Tesla Reveals Its Massive Precursor Supercomputer

June 22, 2021

In spring 2019, Tesla made cryptic reference to a project called Dojo, a “super-powerful training computer” for video data processing. Then, in summer 2020, Tesla CEO Elon Musk tweeted: “Tesla is developing a [neural network] training computer called Dojo to process truly vast amounts of video data. It’s a beast! … A truly useful exaflop at de facto FP32.” Read more…

Google Launches TPU v4 AI Chips

May 20, 2021

Google CEO Sundar Pichai spoke for only one minute and 42 seconds about the company’s latest TPU v4 Tensor Processing Units during his keynote at the Google I Read more…

CentOS Replacement Rocky Linux Is Now in GA and Under Independent Control

June 21, 2021

The Rocky Enterprise Software Foundation (RESF) is announcing the general availability of Rocky Linux, release 8.4, designed as a drop-in replacement for the soon-to-be discontinued CentOS. The GA release is launching six-and-a-half months after Red Hat deprecated its support for the widely popular, free CentOS server operating system. The Rocky Linux development effort... Read more…

Intel Launches 10nm ‘Ice Lake’ Datacenter CPU with Up to 40 Cores

April 6, 2021

The wait is over. Today Intel officially launched its 10nm datacenter CPU, the third-generation Intel Xeon Scalable processor, codenamed Ice Lake. With up to 40 Read more…

Iran Gains HPC Capabilities with Launch of ‘Simorgh’ Supercomputer

May 18, 2021

Iran is said to be developing domestic supercomputing technology to advance the processing of scientific, economic, political and military data, and to strengthen the nation’s position in the age of AI and big data. On Sunday, Iran unveiled the Simorgh supercomputer, which will deliver.... Read more…

10nm, 7nm, 5nm…. Should the Chip Nanometer Metric Be Replaced?

June 1, 2020

The biggest cool factor in server chips is the nanometer. AMD beating Intel to a CPU built on a 7nm process node* – with 5nm and 3nm on the way – has been i Read more…

Leading Solution Providers

Contributors

Julia Update: Adoption Keeps Climbing; Is It a Python Challenger?

January 13, 2021

The rapid adoption of Julia, the open source, high level programing language with roots at MIT, shows no sign of slowing according to data from Julialang.org. I Read more…

AMD-Xilinx Deal Gains UK, EU Approvals — China’s Decision Still Pending

July 1, 2021

AMD’s planned acquisition of FPGA maker Xilinx is now in the hands of Chinese regulators after needed antitrust approvals for the $35 billion deal were receiv Read more…

GTC21: Nvidia Launches cuQuantum; Dips a Toe in Quantum Computing

April 13, 2021

Yesterday Nvidia officially dipped a toe into quantum computing with the launch of cuQuantum SDK, a development platform for simulating quantum circuits on GPU-accelerated systems. As Nvidia CEO Jensen Huang emphasized in his keynote, Nvidia doesn’t plan to build... Read more…

Microsoft to Provide World’s Most Powerful Weather & Climate Supercomputer for UK’s Met Office

April 22, 2021

More than 14 months ago, the UK government announced plans to invest £1.2 billion ($1.56 billion) into weather and climate supercomputing, including procuremen Read more…

Quantum Roundup: IBM, Rigetti, Phasecraft, Oxford QC, China, and More

July 13, 2021

IBM yesterday announced a proof for a quantum ML algorithm. A week ago, it unveiled a new topology for its quantum processors. Last Friday, the Technical Univer Read more…

Q&A with Jim Keller, CTO of Tenstorrent, and an HPCwire Person to Watch in 2021

April 22, 2021

As part of our HPCwire Person to Watch series, we are happy to present our interview with Jim Keller, president and chief technology officer of Tenstorrent. One of the top chip architects of our time, Keller has had an impactful career. Read more…

Frontier to Meet 20MW Exascale Power Target Set by DARPA in 2008

July 14, 2021

After more than a decade of planning, the United States’ first exascale computer, Frontier, is set to arrive at Oak Ridge National Laboratory (ORNL) later this year. Crossing this “1,000x” horizon required overcoming four major challenges: power demand, reliability, extreme parallelism and data movement. Read more…

Senate Debate on Bill to Remake NSF – the Endless Frontier Act – Begins

May 18, 2021

The U.S. Senate today opened floor debate on the Endless Frontier Act which seeks to remake and expand the National Science Foundation by creating a technology Read more…

  • arrow
  • Click Here for More Headlines
  • arrow
HPCwire