Qubit Pharmaceuticals Advances Cancer Research with HPC and AI-Powered Drug Discovery in Collaboration with French Research Institutions

January 30, 2024

PARIS, Jan. 30, 2023 – Qubit Pharmaceuticals, a company specializing in the discovery of new drug candidates using simulation and AI accelerated by hybrid HPC and quantum computing, and Institut Curie, France’s leading center in the fight against cancer, have announced their collaboration in the search for new therapeutic avenues to treat cancer. The project will be carried out in partnership with the Laboratoire de Microbiologie Fondamentale et Pathogénicité at the University of Bordeaux.

As cells proliferate, they can get compressed, and their nuclei can rupture. In a study published in 2021 in the journal Cell, researchers from Institut Curie, Inserm and CNRS have shown that these ruptures allow DNA to come into contact with the TREX1 enzyme, whose usual function is to protect the cell from external threats. As a result, the tumor progresses towards more dangerous invasive stages.

By specifically blocking this enzyme, it should be possible to amplify the efficacy of treatments, as explained by Dr Nicolas Manel, Inserm researcher and head of the “Innate Immunity” team at Institut Curie (Inserm U932), author of the work leading to this discovery: “TREX1 represents a target of great interest, acting on two major therapeutic axes. Successfully inhibiting it would significantly increase the immune response against tumor cells and block metastatic processes.”

All three partners will combine their expertise to inhibit this key agent. This collaborative approach reflects the shared commitment of Qubit Pharmaceuticals, Institut Curie and the University of Bordeaux to explore innovative approaches to the development of more targeted and effective cancer therapies.

The Power of HPC, Simulation and AI to Accelerate the Discovery of Drug Candidates

With its Cancer Immunotherapy Center, the only one of its kind in France, Institut Curie brings together doctors, researchers and healthcare professionals to expand our understanding and develop the immunotherapies of tomorrow. Building on the expertise of Dr Nicolas Manel and his team, Qubit Pharmaceuticals will leverage Atlas, its drug design platform, to generate new molecules with a profile specifically optimized to inhibit this target. Atlas is capable of creating true digital twins of drug candidates, and can predict their interactions extremely accurately and rapidly thanks to high-performance computing. This makes it possible to explore and imagine new molecules that conventional approaches would not have identified.

As soon as these molecules have been identified and synthesized, Dr. Manel’s team at Institut Curie will validate them using biological tests. The University of Bordeaux will carry out biochemical and structural characterizations of the identified leads, thanks to the work of the group led by Dr Paul Lesbats, a CNRS researcher at the Laboratoire de Microbiologie Fondamentale et Pathogénicité, specialized in understanding the consequences of molecular interactions between proteins and their ligands.

The aim is to significantly shorten the early stages of drug candidate discovery in order to bring new therapeutic solutions to patients.

Robert Marino, CEO Qubit Pharmaceuticals, commented: “The fight against cancer is a major objective for Qubit Pharmaceuticals, and we are extremely pleased to be able to collaborate with the Institut Curie in its historic fight for research in this field. Our areas of expertise are complementary. I am convinced that this dual approach combining simulation & AI, and in vivo validation led by expert teams is an opportunity to accelerate the discovery of drug candidates to improve patients’ lives. We are delighted and honored to be working with the Institut Curie & the University of Bordeaux along these lines.”

About Qubit Pharmaceuticals

Qubit Pharmaceuticals was founded in 2020 with the vision of co-developing new, more effective and safer drugs with pharmaceutical and biotech companies. A spin-off from the research work of five internationally renowned scientists – Louis Lagardère (Sorbonne University and CNRS), Matthieu Montes (CNAM), Jean-Philip Piquemal (Sorbonne University and CNRS), Jay Ponder (Washington University in St Louis), Pengyu Ren (University of Texas at Austin) – Qubit Pharmaceuticals leverages its Atlas platform to discover new drugs through simulation and molecular modeling accelerated by hybrid HPC and quantum computing. The multidisciplinary team, led by CEO Robert Marino, and the founders are based in France at the Paris Santé Cochin incubator and in the USA in Boston.


Source: Qubit Pharmaceuticals

Subscribe to HPCwire's Weekly Update!

Be the most informed person in the room! Stay ahead of the tech trends with industry updates delivered to you every week!

U.S. Quantum Director Charles Tahan Calls for NQIA Reauthorization Now

February 29, 2024

(February 29, 2024) Origin stories make the best superhero movies. I am no superhero, but I still remember what my undergraduate thesis advisor said when I told him that I wanted to design quantum computers in graduate s Read more…

pNFS Provides Performance and New Possibilities

February 29, 2024

At the cusp of a new era in technology, enterprise IT stands on the brink of the most profound transformation since the Internet's inception. This seismic shift is propelled by the advent of artificial intelligence (AI), Read more…

Celebrating 35 Years of HPCwire by Recognizing 35 HPC Trailblazers

February 29, 2024

In 1988, a new IEEE conference debuted in Orlando, Florida. The planners were expecting 200-300 attendees because the conference was focused on an obscure topic called supercomputing, but when it was announced that S Read more…

Forrester’s State of AI Report Suggests a Wave of Disruption Is Coming

February 28, 2024

The explosive growth of generative artificial intelligence (GenAI) heralds opportunity and disruption across industries. It is transforming how we interact with technology itself. During this early phase of GenAI technol Read more…

Q-Roundup: Google on Optimizing Circuits; St. Jude Uses GenAI; Hunting Majorana; Global Movers

February 27, 2024

Last week, a Google-led team reported developing a new tool - AlphaTensor Quantum - based on deep reinforcement learning (DRL) to better optimize circuits. A week earlier a team working with St. Jude Children’s Hospita Read more…

AWS Solution Channel

Shutterstock 2283618597

Deep-dive into Ansys Fluent performance on Ansys Gateway powered by AWS

Today, we’re going to deep-dive into the performance and associated cost of running computational fluid dynamics (CFD) simulations on AWS using Ansys Fluent through the Ansys Gateway powered by AWS (or just “Ansys Gateway” for the rest of this post). Read more…

Argonne Aurora Walk About Video

February 27, 2024

In November 2023, Aurora was ranked #2 on the Top 500 list. That ranking was with half of Aurora running the HPL benchmark. It seems after much delay, 2024 will finally be Aurora's time in the spotlight. For those cur Read more…

Royalty-free stock illustration ID: 1988202119

pNFS Provides Performance and New Possibilities

February 29, 2024

At the cusp of a new era in technology, enterprise IT stands on the brink of the most profound transformation since the Internet's inception. This seismic shift Read more…

Celebrating 35 Years of HPCwire by Recognizing 35 HPC Trailblazers

February 29, 2024

In 1988, a new IEEE conference debuted in Orlando, Florida. The planners were expecting 200-300 attendees because the conference was focused on an obscure t Read more…

Forrester’s State of AI Report Suggests a Wave of Disruption Is Coming

February 28, 2024

The explosive growth of generative artificial intelligence (GenAI) heralds opportunity and disruption across industries. It is transforming how we interact with Read more…

Q-Roundup: Google on Optimizing Circuits; St. Jude Uses GenAI; Hunting Majorana; Global Movers

February 27, 2024

Last week, a Google-led team reported developing a new tool - AlphaTensor Quantum - based on deep reinforcement learning (DRL) to better optimize circuits. A we Read more…

South African Cluster Competition Team Enjoys Big Texas HPC Adventure

February 26, 2024

Texas A&M University's High-Performance Research Computing (HPRC) hosted an elite South African delegation on February 8 - undergraduate computer science (a Read more…

A Big Memory Nvidia GH200 Next to Your Desk: Closer Than You Think

February 22, 2024

Students of the microprocessor may recall that the original 8086/8088 processors did not have floating point units. The motherboard often had an extra socket fo Read more…

Apple Rolls out Post Quantum Security for iOS

February 21, 2024

Think implementing so-called Post Quantum Cryptography (PQC) isn't important because quantum computers able to decrypt current RSA codes don’t yet exist? Not Read more…

QED-C Issues New Quantum Benchmarking Paper

February 20, 2024

The Quantum Economic Development Consortium last week released a new paper on benchmarking – Quantum Algorithm Exploration using Application-Oriented Performa Read more…

Training of 1-Trillion Parameter Scientific AI Begins

November 13, 2023

A US national lab has started training a massive AI brain that could ultimately become the must-have computing resource for scientific researchers. Argonne N Read more…

Alibaba Shuts Down its Quantum Computing Effort

November 30, 2023

In case you missed it, China’s e-commerce giant Alibaba has shut down its quantum computing research effort. It’s not entirely clear what drove the change. Read more…

Nvidia Wins SC23, But Gets Socked by Microsoft’s AI Chip

November 16, 2023

Nvidia was invisible with a very small booth and limited floor presence, but thanks to its sheer AI dominance, it was a winner at the Supercomputing 2023. Nv Read more…

Nvidia H100: Are 550,000 GPUs Enough for This Year?

August 17, 2023

The GPU Squeeze continues to place a premium on Nvidia H100 GPUs. In a recent Financial Times article, Nvidia reports that it expects to ship 550,000 of its lat Read more…

Analyst Panel Says Take the Quantum Computing Plunge Now…

November 27, 2023

Should you start exploring quantum computing? Yes, said a panel of analysts convened at Tabor Communications HPC and AI on Wall Street conference earlier this y Read more…

Royalty-free stock illustration ID: 1675260034

RISC-V Summit: Ghosts of x86 and ARM Linger

November 12, 2023

Editor note: See SC23 RISC-V events at the end of the article At this year's RISC-V Summit, the unofficial motto was "drain the swamp," that is, x86 and Read more…

China Deploys Massive RISC-V Server in Commercial Cloud

November 8, 2023

If the U.S. government intends to curb China's adoption of emerging RISC-V architecture to develop homegrown chips, it may be getting late. Last month, China Read more…

DoD Takes a Long View of Quantum Computing

December 19, 2023

Given the large sums tied to expensive weapon systems – think $100-million-plus per F-35 fighter – it’s easy to forget the U.S. Department of Defense is a Read more…

Leading Solution Providers

Contributors

Shutterstock 1285747942

AMD’s Horsepower-packed MI300X GPU Beats Nvidia’s Upcoming H200

December 7, 2023

AMD and Nvidia are locked in an AI performance battle – much like the gaming GPU performance clash the companies have waged for decades. AMD has claimed it Read more…

Intel’s Server and PC Chip Development Will Blur After 2025

January 15, 2024

Intel's dealing with much more than chip rivals breathing down its neck; it is simultaneously integrating a bevy of new technologies such as chiplets, artificia Read more…

Baidu Exits Quantum, Closely Following Alibaba’s Earlier Move

January 5, 2024

Reuters reported this week that Baidu, China’s giant e-commerce and services provider, is exiting the quantum computing development arena. Reuters reported � Read more…

Chinese Company Developing 64-core RISC-V Chip with Tech from U.S.

November 13, 2023

Chinese chip maker SophGo is developing a RISC-V chip based on designs from the U.S. company SiFive, which highlights challenges the U.S. government may face in Read more…

Royalty-free stock illustration ID: 1182444949

Forget Zettascale, Trouble is Brewing in Scaling Exascale Supercomputers

November 14, 2023

In 2021, Intel famously declared its goal to get to zettascale supercomputing by 2027, or scaling today's Exascale computers by 1,000 times. Moving forward t Read more…

Synopsys Eats Ansys: Does HPC Get Indigestion?

February 8, 2024

Recently, it was announced that Synopsys is buying HPC tool developer Ansys. Started in Pittsburgh, Pa., in 1970 as Swanson Analysis Systems, Inc. (SASI) by John Swanson (and eventually renamed), Ansys serves the CAE (Computer Aided Engineering)/multiphysics engineering simulation market. Read more…

Comparing NVIDIA A100 and NVIDIA L40S: Which GPU is Ideal for AI and Graphics-Intensive Workloads?

October 30, 2023

With long lead times for the NVIDIA H100 and A100 GPUs, many organizations are looking at the new NVIDIA L40S GPU, which it’s a new GPU optimized for AI and g Read more…

Shutterstock 1179408610

Google Addresses the Mysteries of Its Hypercomputer 

December 28, 2023

When Google launched its Hypercomputer earlier this month (December 2023), the first reaction was, "Say what?" It turns out that the Hypercomputer is Google's t Read more…

  • arrow
  • Click Here for More Headlines
  • arrow
HPCwire